Safety and Efficacy of Remote Ischemic Conditioning Combined With Intravenous Thrombolysis for Acute Ischemic Stroke

Inclusion Criteria: * 1\) Age≥18 years, regardless of sex; * 2\) Patients with a clinically definite diagnosis of acute ischemic stroke and undergo intravenous thrombolysis with alteplase; * 3\) Pre-thrombolysis NIHSS \>= 4, and \<= 24; * 4\) Premorbid mRS 0-1; * 5\) Signed and dated informed consent is obtained; Exclusion Criteria: * 1\) Patients who have the contraindication of intravenous thrombolysis with alteplase. * 2\) The patients who have the contraindication of remote ischemic conditioning treatment, such as severe soft tissue injury, fracture or vascular injury in the upper limb. * 3\) Acute or subacute venous thrombosis, arterial occlusive disease, subclavian steal syndrome, etc. * 4\) Pregnant or lactating women. * 5\) Severe hepatic and renal dysfunction. * 6\) Patients with a life expectancy of less than 3 months or patients unable to complete the study for other reasons. * 7\) Unwilling to be followed up or treated for poor compliance. * 8\) He/She is participating in other clinical research or has participated in other clinical research or has participated in this study within 3 months prior to admission. * 9\) Other conditions that the researchers think are not suitable for the group.