Observational Study of Neuromuscular Function in CMT Type 1&2 and Healthy Controls

Inclusion Criteria for CMT Patients * Age ≥ 18 years * Diagnosis of CMT confirmed by: * Clinical presentation and electro diagnostics or genetics * Physical Features (all must apply): 1) Ambulation for at least 10 meters, without a brace 2) Left and right ankle plantar flexion Medical Research Council (MRC) grade 2 to 5, inclusive 3) Left and right ankle dorsiflexion MRC manual muscle testing (MMT) grade 2 to 4+, inclusive. * Ability to adhere to the study visit schedule/procedures, and to understand and comply with protocol requirements * Stable concomitant medications for 2 months prior to enrolment * Signed written informed consent Exclusion Criteria for CMT Patients * Severe deformity or ankle contracture that would sufficiently limit passive range of motion to affect assessment of dorsiflexion strength * Ulceration that would interfere with functional ability * Recent major surgery * Significant change in physical activity or exercise (e.g., significant increase or decrease in intensity or frequency) within 8 weeks before Study Day 1 or inability to maintain the baseline level of physical activity throughout the study * Any disability or condition that would prevent completion of the study tasks * Moderate to severe Neuropathic or inflammatory/musculoskeletal pain that would interfere with performance of the tests * A diagnosis of a primary NMJ disorder such as myasthenia gravis, Lambert Eaton Myasthenic Syndrome or congenital myasthenic disorder Inclusion Criteria for Healthy Volunteers * Healthy male or female volunteers * Age ≥18 years * Able to give written informed consent Exclusion Criteria for Healthy Volunteers * Pregnant * Requiring prescription medicines likely to interfere with electromyography (EMG) recordings * Presence of current or previous medical condition which might interfere with participation in the study