Zebutinib Combined With Immunochemotherapy in the Treat of Newly Treated CLL Patients Without 17p-/TP53 Mutation

Inclusion Criteria: * CLL patients with indications for treatment according to iwCLL; * CT/MRI shows measurable lesions; * ECOG score is 0-2; * No pregnancy plans during treatment Exclusion Criteria: * Richter transformation; * 17p-/TP53 amplification ≥20% (FISH); * Received steroids within 7 days before starting treatment; * Have previously received treatments for chronic lymphocytic leukemia; * Vaccine live attenuated vaccine within 4 weeks of randomization; * Any life-threatening disease; * Central nervous system leukemia; * Apoplexy, history of intracranial hemorrhage; * HIV or HCV or HBVpositive