This topic foe randomized prospective study.Detection of elderly patients with lunmbar spinal postoperative inflammatory substances in the blood and drainage of liquid level ,clear whether low-dose dexamethasone can inhibit the inflammation, the observation of elderly patients with lumbar spinal postoperative drainage star, to explor whether low-dose dexamthasone can reduce postoperative incision drainage, thus impove the postoprative drainage tube pull rate within three days, which in turn reduce because of the place a retrograde infection caused by drainage tube.
A total of 100 patients undergoing posterior lumbar disc fusion were randomly divided into control group (group C,n=50) and dexamethasone group (group D,n=50). Group D was given 0.15mg/kg dexamethasone (2ml) intravenously after anesthesia induction. Group C was also intravenously injected with 2ml normal saline after anesthesia induction.On this basis, monitor the main results and secondary results
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
120
Intravenous injection after induction of anesthesia Injection 0.15mg/kg dexamethasone (2ml)
2ml of normal saline was injected intravenously after induction of anesthesia
General Hospital of Ningxia Medical University
Yinchuan, Ningxia, China
the change of drainage fluid volume
Drainage fluid （ml）was collected and the volume of drainage fluid was recorded Until the drainage tube was pulled out,
Time frame: 6 hours after surgery， the morning of 1, 2, and 3 days after surgery
the change of Inflammatory mediators in the drainage fluid
CRP(mg/ L) in postoperative drainage fluid was observed
Time frame: 6 hours after surgery， the morning of 1, 2, and 3 days after surgery
the change of blood inflammatory mediators
Fasting blood was collected from each enrolled patient preoperatively, 6 hours after surgery and on the morning of 1, 2, and 3 days after surgery Fasting blood, blood samples were centrifuged (1500r/min, 15min) and serum was separated and placed in -80℃ deep low temperature refrigerator for measurement. The observation technique After the blood CRP(mg/l)
Time frame: 6 hours after surgery， the morning of 1, 2, and 3 days after surgery
the change of blood routine white blood cell count
Fasting blood was collected from each enrolled patient preoperatively, 6 hours after surgery and on the morning of 1, 2, and 3 days after surgery Fasting blood, blood samples were centrifuged (1500r/min, 15min) and serum was separated and placed in -80℃ deep low temperature refrigerator for measurement. The observation technique After the blood blood routine white blood cell count
Time frame: 6 hours after surgery， the morning of 1, 2, and 3 days after surgery
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.