Real-world Evidence of COVID-19 Vaccines Effectiveness

Ivan S Moiseev182 enrolled

Overview

This is an observational case-control study to evaluate COVID-19 vaccine effectiveness against hospitalisation with COVID-19 related conditions in St. Petersburg, Russia. Two sets of cases and control will be retrospectively analyzed to compare vaccination proportions and other characteristics to infer vaccine effectiveness from odds ratios. The first set of cases will be extracted from the data on hospitalisation of patients with COVID-19 to First Pavlov State Medical University of Saint-Petersburg hospitals, and controls will be patients hospitalised with other conditions. The second set of cases and controls will be based on patients referred to Medical Institute named after Berezin Sergey for computed tomography. Cases will be patients with positive SARS-CoV-2 status computed tomography confirmed pneumonia or patients referred to hospitalisation, and control will be patients without pneumonia and not referred to hospitalisation.

Study Type

OBSERVATIONAL

Enrollment

182

Conditions

COVID-19 Pneumonia

Interventions

COVID-19 VaccinesBIOLOGICAL

"Gam-COVID-Vac" "EpiVacCorona" "COVIVAC"

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients hospitalized to clinics of First Pavlov State Medical University of Saint-Petersburg * Patients referred to Medical Institute named after Berezin Sergey for computed tomography * Available vaccination status Exclusion Criteria: \- Refusal to provide information for research purposes at the time of hospitalization or reference to computed tomography

Locations (2)

Mikhail Cherkashin

Saint Petersburg, Sankt-Peterburg, Russia

Oksana Stanevich

Saint Petersburg, Russia

Outcomes

Primary Outcomes

Effectiveness of full vaccination against hospitalization with COVID-19 pneumonia

Full vaccination effectiveness is calculated based on the odds ratio of vaccination proportions in cases and controls, adjusted for other patient characteristics. Full vaccination status is assigned after two weeks of the second dose for each vaccine separately.

Time frame: 3 months

Secondary Outcomes

Effectiveness of partial vaccination against hospitalization with COVID-19 pneumonia

Partial vaccination effectiveness is calculated based on the odds ratio of vaccination proportions in cases and controls, adjusted for other patient characteristics. Partial vaccination status is assigned after two weeks of the first dose for each vaccine separately.

Time frame: 3 months

Effectiveness of vaccination against hospitalization with COVID-19 pneumonia in different age groups

Evaluate vaccine effectiveness in different age groups (\<20, 20-29, 30-39, 40-49, 50-59, 60-69, \>70)

Time frame: 3 months