Comparative Study Between Combined Vaginal Misoprostol

Cairo University60 enrolled

Overview

"Comparative study between Combined Vaginal Misoprostol with Isosorbide-5-Mononitrate

"Comparative study between Combined Vaginal Misoprostol with Isosorbide-5-Mononitrate versus Misoprostol Alone For Induction Of The first trimester Missed Abortion A Randomized Clinical Trial"

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Missed Abortion

Interventions

Misoprostol and iso sorbide mononitratesDRUG

drug

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * \- Maternal Age 18 - 35 years. * Gestational age first trimester of pregnancy (between 5-13 weeks). * Missed abortion confirmed by ultrasound. * Singleton pregnancy. * Normal uterus and cervix on clinical examination. * Cervix is not dilated. * No vaginal bleeding. Exclusion Criteria:- Evidences suggesting start of spontaneous abortion and previous trial to induce abortion. * Presence of uterine contraction or bleeding, * Multi-fetal pregnancy. * Suspicion of septic abortion. * History of Previous cervical surgery or manipulation. Ex: cervical tear , cervical cauterization . * Uterine anomaly. * Presence of IUD( intrauterine device) in situ * Underlying medical diseases.Ex:diabetes mellitus,hypertension * History of allergy or adverse effects to vaginally administered medication e.g. isosorbide -5- mononitrate * Those unwilling to participate in the trial * Higher order cesarean section(more than three

Locations (1)

Cairo U

Cairo, Married, Egypt

Outcomes

Primary Outcomes

Induction to abortion interval

Induction to abortion interval: the Duration interval between the beginning of the induction and beginning of cervical ripening assessed by cervical examination(cervix become soft and start to dilate) and uterine contractions leading to complete expulsion of the abortus spontaneous and if cervical ripening isn't occur by maximum doses the investigators will make surgical evacuation.

Time frame: 6 months

Number of the doses

the Number of the doses of misoprostol needed to complete expulsion (spontaneous or surgical)

Time frame: 6 months

Data from ClinicalTrials.gov

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