Interoception in Anorexia Nervosa

Fondation Santé des Étudiants de France50 enrolled

Overview

Anorexia nervosa is a serious psychiatric illness whose causes remain poorly understood, and which remains difficult to treat to this day. Many clinical manifestations of this disease can have their origin in abnormalities in the perception of signals coming from inside the body, but this remains to be demonstrated. In recent years, research in healthy subjects has shown how the brain constantly perceives the viscera (heart, lungs, stomach). The examiners will use these new, objective and validated methods to explore how the brain processes information from the viscera (interoception) in anorexic patients. In practice, they will quantify the coupling between the cardiac cycle and involuntary eye movements, as well as between the respiratory cycle and voluntary actions such as pressing a button. Finally, by simultaneously recording the electrical activity of the brain, and that of the stomach, the examiners will measure the coupling between the brain and the stomach. All these measurements, which will be compared between a population of patients and healthy subjects, will make it possible to determine whether anorexic patients have an alteration in the perception of their internal body signals and whether this damage affects several organs.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Anorexia Anorexia Nervosa Electrocardiogram EEG

Interventions

Clinical and experimental sessionOTHER

Psychologic profile with standardized interview and scales (see below for details: SCID, BDI, STAI, BPQ, EDE Q, Pictorial Body Image Scale (PBIS) and EDI). Measure the stomach-brain synchrony during EEG/EGG resting state, the distribution of voluntary actions across the respiratory phase, and the distribution of saccadic eye movements across the cardiac-cycle.

Eligibility

Sex: FEMALEMin age: 16 YearsMax age: 25 Years

Medical Language ↔ Plain English

Inclusion Criteria - AN groups: * Females * 6 to 25 years old * Diagnostic of AN according to DSM-5 criteria * No past or current psychotic disorders * No current substance abuse or dependence (excluding tobacco). * No current psychiatric medication Inclusion Criteria - control groups: * Females * Age : matched for the AN group * No present or past eating disorders * No past or current psychotic disorders * No current substance abuse or dependence. * No current psychiatric medication Exclusion Criteria for both groups: * age below 16 years and above 25 years, * Past or current psychotic disorders, * Current substance abuse or dependence (excluding tobacco) * Opposition to participation has been expressed. In addition, for the control group, * Subjects with present or past eating disorders or current mental disorders will be excluded.

Outcomes

Primary Outcomes

measure brain-stomach interactions using phase-amplitude coupling between the gastric phase and the amplitude of the cortical alpha rhythm.

Examiners will directly measure brain-stomach interactions using phase-amplitude coupling between the gastric phase and the amplitude of the cortical alpha rhythm.

Time frame: Experimental session - 10 days maximum after inclusion