Treating Congestive HF With hiPSC-CMs Through Endocardial Injection

Inclusion Criteria: 1. Patients aged 18-75 years (including 18 and 75). 2. Signed the informed consent. 3. Patients with congestive heart failure who have received regular treatment for heart failure. 4. New York Heart Association (NYHA) Class III or IV despite optimal standard of care 5. Left Ventricular Ejection Fraction (LVEF)\<40% as assessed by echocardiography ( measure in the 3 months of recruit is included, excluding the measured values within 1 month of myocardial infarction ） 6. The thickness of left ventricular ≥8mm 7. Female patient who is not pregnant or nursing during the clinical trial Exclusion Criteria: 1. PRA ≥ 20% or DSA positive. 2. Patients received treatments such as pacemakers, ICD or CRT device. 3. Patient with severe valvular disease or presence of a mechanical valve replacement, such as PCI implantation, or patients requiring simultaneous radiofrequency ablation of atrial fibrillation. 4. Patient with any therapeutic traumatic heart surgery within 30 days. 5. Hemodynamic instability or cardiogenic shock. 6. Right heart failure. 7. Restrictive cardiomyopathy such as amyloidosis, sarcoidosis or hematochromia, constrictive pericarditis. 8. Myocardial infarction occurred within 30 days or stroke occurred within 60 days before enrollment. 9. Thickness at left ventricular free wall infarction \< 6 mm. 10. Severe ventricular arrhythmias (persistent ventricular tachycardia or other conditions that the investigator considers necessary to exclude). 11. Baseline glomerular filtration rate \< 30 ml/min / 1.73 m2. 12. Abnormal liver function: ALT or AST 3 times higher than the normal value. 13. Have a hematologic abnormality as evidenced by hematocrit \< 25%, white blood cells count \<2,500/ul or platelet count \<100000 / ul. 14. Known allergies to penicillin, streptomycin or radiocontrast agent. 15. Abnormal coagulation function, INR \> 1.3, which cannot be corrected. 16. Contra-indication to performance of a magnetic resonance imaging scan and PET/ECT examinations. 17. Organ transplant recipient 18. Patients with other malignant disease within 5 years prior to enrollment. 19. Non-cardiac condition that limits lifespan to \< 1 year 20. On chronic therapy with immunosuppressant medication such as glucocorticoid or TNFα antagonist 21. Contra-indication to take immunosuppressant medication. 22. Serum positive for infectious diseases (HIV, HBV, HCV, TP). 23. Participated in other clinical trials within the previous 3 months . 24. Female patient who is pregnant or nursing. 25. Other condition that the investigator considers inappropriate for participation in the study.