Effects of Different Polyphenol-containing Beverages on the Immune System and on Muscular Growth Factors

Balgrist University Hospital20 enrolled

Overview

In this research project, the effect of different polyphenol-containing beverages with varying alcohol content of \< 0.4 vol% on immune function as well as muscular growth factors will be investigated

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Enrollment

Conditions

Food Sensitivity

Interventions

non-alcoholic PilsnerOTHER

intake of 1 L non-alcoholic Pilsner per day for 2 weeks

non-alcoholic wheat beerOTHER

intake of 1 L non-alcoholic wheat beer per day for 2 weeks

apple spritzerOTHER

intake of 1 L apple spritzer per day for 2 weeks

Eligibility

Sex: ALLMin age: 20 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy * Age 20 - 60 years * Written informed consent Exclusion Criteria: * severe gastrointestinal disease or known malabsorption * use of proton pump inhibitors * malignancies * rheumatoid diseases * metabolic syndrome * acute or chronic infections or inflammatory diseases * use of medications or supplements to interfere with immune function * alcohol and/or drug abuse or addiction * dependent relationship with the project manager or his or her employees * pregnancy or breastfeeding * chronic illness or regular use of medication (except hormonal contraception) * smoker

Locations (1)

Balgrist University Hospital

Zurich, Switzerland

Outcomes

Primary Outcomes

white blood cells

white blood cell count

Time frame: before beverage intake

white blood cells

white blood cell count

Time frame: 60 minutes after intake

white blood cells

white blood cell count

Time frame: 120 minutes after intake

inflammatory markers in the blood

IL-6, TNF- α, hs-CRP

Time frame: before beverage intake

inflammatory markers in the blood

IL-6, TNF- α, hs-CRP

Time frame: 60 minutes after intake

inflammatory markers in the blood

IL-6, TNF- α, hs-CRP

Time frame: 120 minutes after intake

blood alcohol

blood alcohol level

Time frame: before beverage intake

blood alcohol

blood alcohol level

Time frame: 60 minutes after intake

blood alcohol

blood alcohol level

Time frame: 120 minutes after intake

white blood cells

white blood cell count

Time frame: after 14 days of daily intake

Data from ClinicalTrials.gov

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Secondary Outcomes

dietary habit

3 day food diary

Time frame: before beverage intake and day 12-14 of beverage intake

dietary habit

3 day food diary

Time frame: day 12-14 of beverage intake

physical activity

Global Physical Activity Questionnaire (allows to calculate metabolic equivalents to express the intensity of physical activities

Time frame: before beverage intake

physical activity

Global Physical Activity Questionnaire (allows to calculate metabolic equivalents to express the intensity of physical activities

Time frame: day 14 of beverage intake