Optimization of the Core Number and Location for Targeted Prostate Biopsy

Inclusion Criteria: 1. Men more than 18 years old with clinical suspicion of prostate cancer; 2. Serum PSA ≤ 20 ng/ml within the previous 3 months; 3. No evidence of PSA increase by noncancerous factors, such as catheterization, bladder stones, or urinary tract infection including bacterial prostatitis; 4. mpMRI PI-RADS V2.1 score ≥4, diameter of ≤2.5 cm； 5. Able to provide written informed consent. Exclusion Criteria: 1. Prior prostate biopsy or prostate surgery; 2. Prior treatment for prostate cancer; 3. Contraindication to MRI (e.g. claustrophobia, pacemaker); 4. Contraindication to prostate biopsy; 5. Men in whom artifact would reduce the quality of the MRI.