A Study to Evaluate Breathing Muscle Training in Cardiac Rehab

Mayo Clinic42 enrolled

Overview

The purpose of this study is to understand if breathing muscle training combined with cardiac rehabilitation influences the blood flow and blood pressure response during exercise.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Enrollment

Conditions

Healthy Heart Failure

Interventions

Inspiratory muscle trainingDEVICE

Inspiratory muscle training for 12 weeks at 40% maximal inspiratory pressure

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria - Heart Failure Group: * Adult 18 years and older. * English speaking. * Has a qualifying heart failure indication for center-based cardiac rehabilitation. Inclusion Criteria - Healthy Control Group: * Adult 18 years and older. * English speaking. * Absence of pulmonary, cardiovascular, musculoskeletal, neurologic, or orthopedic diseases. Controls will be matched for age and sex. Exclusion Criteria: * HF patients who are unable to engage in a regularly structured exercise training program as part of a clinically indicated center-based outpatient cardiac rehabilitation program. * Participants unable/unwilling to provide informed consent. * Uremia, history of allergy to iodides. Impaired renal function. * Creatinine value greater than 1.3 mg/dL (via clinical record within the past 6 months). * Diagnosis of liver disease.

Locations (1)

Mayo Clinic in Rochester

Rochester, Minnesota, United States

RECRUITING

Outcomes

Primary Outcomes

Blood pressure response

Mean arterial pressure

Time frame: baseline and 12 week follow up

Change in blood flow response

respiratory muscle blood flow

Time frame: baseline and 12 week follow up

Change in limb vascular resistance response

Limb vascular resistance

Time frame: baseline and 12 week follow up

Central Contacts

Eric Bruhn, MA

CONTACT

507-266-2690 bruhn.eric@mayo.edu

Joshua Smith

CONTACT

smith.joshua1@mayo.edu

Data from ClinicalTrials.gov

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