Lipid Metabolism in Obese Subjects Undergoing Bariatric Surgery

University of Cagliari68 enrolled

Overview

The aim of the study is to evaluate modifications in the metabolism of polyunsaturated fatty acids (PUFA) and biosynthesis of the lipid mediators N-acylethanolamines (NAE), both known to induce and be induced by the nuclear peroxisome proliferator-activated receptor (PPAR)-α, which may also explain the well-established improved lipid and energy metabolism after bariatric surgery. The study is focused on understanding the weight loss mechanisms in order to develop targeted dietary protocols.

The study involves a careful preliminary medical history of the patients, with physical examination, anthropometric parameters measurements and blood sampling for blood chemistry routine and evaluation of any adverse events to assess suitability for the study. The evening before bariatric surgery, one month and six months after bariatric surgery anthropometric parameters measurements, blood sampling for blood chemistry routine, inflammatory and lipid-metabolomic profile, and evaluation of any adverse events are performed. For the study samples are stored identified by a code to be analyzed anonymously. Study interruption criteria are: development of allergic reactions, ketonemia\> 1.5 mmol/L, acute gout

Study Type

OBSERVATIONAL

Enrollment

Conditions

Bariatric Surgery Candidate Lipid Metabolism Disorders Obesity

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * subjects with pathological obesity suitable for bariatric surgery * Body Mass Index (BMI) range 35-59 Exclusion Criteria: * established diagnoses of a major disease (e.g., diabetes or kidney disease) * pregnancy or breastfeeding, * food allergies, * use of drugs that could affect lipid metabolism

Locations (1)

Centro di Chirurgia Bariatrica dell'Azienda Ospedaliera G. Brotzu

Cagliari, Italy

Outcomes

Primary Outcomes

Modifications of Endocannabinoid and N-acylethanolamine plasma levels

These lipid derivatives are involved in control of energy expenditure and lipid metabolism and are measured by LC MS/MS and expressed as nmol/ml plasma

Time frame: 6 months

Weight loss as kg, and fat mass reduction as total kg and percent of body mass

Indicators of the success of the intervention

Time frame: 6 months

Changes in fatty acid plasma profile induced by bariatric surgery

Fatty acid profile affect lipid derivatives. Fatty acid are measured by LC and GC and expressed as nmol/ml plasma

Time frame: 6 months

Data from ClinicalTrials.gov

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