Major depressive disorder (MDD) is a common mental illness with high prevalence and global burden. Previous studies revealed that over 70% patients in remission still had decreased quality of life, severe function impairment, low positive mental health score and poor coping ability. However, few studies focus on working and school age patients with MDD. A GBD survey showed that over 40% MDD patients are 15-50 years old. Therefore, we initiate the present multi-center cross-sectional survey to investigate the associations between clinical symptoms, cognitive function, occupational/study ability, and quality of life in Chinese working and school age population with MDD who are in remission.
This is a multi-center cross-sectional study. Patients with MDD who received medication treatment and achieved remission for at least 8 weeks will be enrolled. For all the participants, demographic information will be collected; clinical symptoms, cognitive function, occupational/study ability, and quality of life will be evaluated by using 17-items HAMD, PHQ-9, HAMA, PSQI, SHAPS, HCL-32, SDS, LEAPS, QOL-6, PFQ and THINC-it toolkit.
Study Type
OBSERVATIONAL
Enrollment
500
No inervention. Treatment regime remains unchanged.
Shanghai Mental Health Center
Shanghai, China
RECRUITINGThe Sheehan disability scale (SDS)
To evaluate the functional impairment, including work/study, daily life and family responsibility. The score of each subscale ranged from 0 to 10 which means from no impairment to loss of function.
Time frame: up to 1 weeks
Quality of Life, short form 6 (QOL-6)
To evaluate the quality of life in patients with MDD. The higher the total score, the better the quality of life.
Time frame: up to 4 weeks
The Psychosocial Function Questionnaire in Patients with Depression (PFQ)
To evaluate the psychosocial function of patients with MDD. The lower total score means the severer psychosocial function impairment.
Time frame: up to 1 weeks
The Lam Employment Absence and Productivity Scale (LEAPS)
To evaluate the work capacity. The higher total score means the severer impairment of work capacity.
Time frame: up to 2 weeks
The Hamilton Depression Scale-17 items (HAMD)
To evaluate the severity of depressive symptoms by clinicians. Remission: total score \< 7.
Time frame: up to 1 weeks
Patient Health Questionnaire-9 (PHQ-9)
to evaluate the severity of depressive symptoms by patients. Remission: total score \< 4.
Time frame: up to 2 weeks
The Hamilton Anxiety Scale (HAMA)
To evaluate the severity of anxiety symptoms by clinicians. The total score \< 6: no anxiety sympotom.
Time frame: up to 1 weeks
Pittsburgh Sleep Quality Index (PSQI)
To evaluate the sleep quality. The lower the total score, the better sleep quality (\<5).
Time frame: up to 4 weeks
The Snaith-Hamilton Pleasure Scale (SHAPS)
To evaluate the severity of anhedonia. The higher total score means the severer of anhedonia.
Time frame: up to 4 weeks
THINC-it toolkit
To assess the cognitive function in patients with MDD specifically. The composite THINC-it tool score is the integrated total score of results from performance on five sub-component cognitive tests of the THINC-it tool.
Time frame: up to 1 weeks
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