This study was done to evaluate the efficacy of Tranexamic Acid (TXA) in reducing blood transfusion requirement in patients of lower limb trauma undergoing surgery.
This was a single centre, parallel group, prospective randomized control study. 116 patients of lower limb trauma presented between April 2017 to August 2018 at Civil Hospital Rajpura. 16 patients were excluded due to old fracture, percutaneous wire fixation or non-consenting patient. The remaining 100 patients were randomized into two groups. 50 patients were given 1 gram of TXA before surgery and 50 patients were not given TXA. Fall in Hb, requirement of blood transfusion, number of days admitted in the hospital after surgery and evidence of deep vein thrombosis were monitored.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
100
1 g of TXA in 100 ml of normal saline
100 ml
APJain Civil Hospital, Rajpura
Patiāla, Punjab, India
Requirement of number of units of blood transfusion
From the date of surgery till time of discharge
Time frame: Average of 15 days
Evidence of deep vein thrombosis by Wells Score
Based on Wells et al Clinical model for DVT
Time frame: Average of 15 days (From the date of surgery till time of discharge)
Change in Haemoglobin level post surgery
From the date of surgery till time of discharge
Time frame: Average of 15 days (From the date of surgery till time of discharge)
Number of days admitted in the hospital after surgery
From the date of admission till time of discharge
Time frame: Average of 15 days (From the date of admission till time of discharge)
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