Cranberries are traditionally used for urinary comfort and prevention of urinary disorders of bacterial origin and despite an EFSA opinion invalidating the clinical efficacy of cranberries, its mechanism of action has been several times proposed by the scientific community: it would act by inhibiting the synthesis of P-fimbriae leading to a complete disappearance of these adhesins, and to bacterial-type deformation by lengthening of the cell body. Cinnamon and microbiotic strains could enhance this synergy. This study aims to evaluate the effectiveness of a food supplement based on cranberry, cinnamon and microbiotic strains (Feminabiane CBU) on the symptoms of cystitis, urinary discomfort and the number of cystitis reported by women.
Women who use or not the cranberry, cinnamon, and microbiotic blend are encouraged to complete a 6-month diary in which they report any urinary tract disorders they encounter.
Study Type
OBSERVATIONAL
Enrollment
80
EXTRACTS OF CRANBERRY, CINNAMON AND MICROBIOTIC STRAINS
CEN Nutriment
Dijon, Bourgogne-Franche-Comté, France
CEN Nutriment
Dijon, Burgundy, France
Occurence of symptomatic cystitis-like episodes
Number of symptomatic cystitis-like episodes reported by the subject self-assessed using the "typical" domain of the Acute Cystitis Symptom Score (ACCS) and defined by a score ranged between 6 to 18.
Time frame: At week 24
Change of the quality of life related to urinary discomfort
ACCS "Quality of life" domain ranged between 0 (better) and 9 (worse)
Time frame: At weeks 0, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24
Severity of urinary discomfort
Global ACCS score ranged between 0 (better) and 39 (worse)
Time frame: Every day during each urinary symptoms (Week 0 to Week 24)
Time-period without antibiotics
Measurement of the time interval between 2 antibiotic therapies if applicable
Time frame: At week 24
Mean time to onset of symptomatic episodes of the cystitis
Measurement of the time interval between 2 symptomatic episodes of the cystitis
Time frame: At week 24
Effect of blend consumption in preventing symptomatic episode of cystitis
Comparison of the rate of women blend users versus non-users who did not reported any symptomatic episode of cystitis as defined by a 0 score for the "typical" domain of the Acute Cystitis Symptom Score (ACCS).
Time frame: At week 24
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.