This phase II trial studies the use of Ion robotic bronchoscope with a mobile computed tomography (CT) scanner to biopsy tumors and inject a fluorescent dye called indocyanine green to mark the tumor during surgery in patients with stage I non-small cell lung cancer or cancer that has spread to the lung (lung metastases). Sometimes small tumors or those that are not on the surface of the lung can be challenging to remove without making larger incisions. Injecting the dye, may help doctors see the tumor more easily, which may allow for smaller incisions and by being able to see the tumor, doctors may be better able to decide where to make the incisions in order to get all of the tumor out.
PRIMARY OBJECTIVE: I. To evaluate the feasibility of using the Ion Endoluminal Platform (IEP; Intuitive, Sunnyvale, California \[CA\]) with the Cios Spin - a mobile cone-beam C - (Siemens Medical Solutions, Malvern, Pennsylvania \[PA\], United States \[US\]) in the operating room setting. OUTLINE: During standard of care surgical resection, patients undergo robotic bronchoscopy and CT. Patients also receive indocyanine green via injection.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DEVICE_FEASIBILITY
Masking
NONE
Undergo CT
Given via injection
Undergo bronchoscopy using Ion robotic bronchoscope
M D Anderson Cancer Center
Houston, Texas, United States
Number of successful procedures out of 50
Success is defined as the ability of the provider to navigate to the lesion and deploy the needle into the lesion using the three allotted scans to aid in targeting to the lesion (As evaluated by surgeon using cone beam computed tomography \[CT\]).
Time frame: through study completion, an average of 1 year
Number of repositions required to deploy needle into lesion
Time frame: through study completion, an average of 1 year
Presence or absence of diagnostic tissue in sample
Evaluated using rapid cytology.
Time frame: Up to 2 years
Indocyanine green visualized during robotic pulmonary resection
Time frame: through study completion, an average of 1 year
Number of cases that were begun as robotic or video-assisted that were converted to open in order to palpate nodule
Time frame: through study completion, an average of 1 year
Closest margin on resected nodule pathology
Time frame: Up to 2 years
Proximity of needle to the lesion on first deployment
Evaluated retrospectively by research fellow using cone beam CT images.
Time frame: through study completion, an average of 1 year
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