Time Restricted Feeding on Nonalcoholic Fatty Liver Disease ( TREATY-FLD )：a 12-month Follow-up Study

Inclusion Criteria: 1. Man or women aged≥18 years; 2. Subjects with NAFLD determined by MRI (intrahepatic triglyceride content ≥5%); 3. Body mass index (BMI)of 28.0 to 45.0 kg/m2; Exclusion Criteria: 1. History of alcoholic liver disease, chronic viral hepatitis, drug-induced hepatitis, autoimmune hepatitis, cirrhosis, and liver cancer; 2. History of HIV, or active pulmonary tuberculosis; 3. Diagnosis of type 1 and type 2 diabetes; 4. History of malignant tumors; 5. Serious liver dysfunction or chronic kidney disease (AST or ALT \> 3 times the upper limit of normal, or eGFR\<30 ml/min/1.73 m2); 6. Significant alcohol consumption in the past six months (Consumed more than 20 g/day for women or 30 g/day for men); 7. History of serious cardiovascular or cerebrovascular disease (angina, myocardial infarction or stroke) in the past 6 months; 8. History of severe gastrointestinal diseases or gastrointestinal surgery in the past 12 months; 9. History of Cushing's syndrome, hypothyroidism, acromegaly, hypothalamic obesity; 10. Being a smoker or having been a smoker in the 3 months prior to their screening visit; 11. Taking medications affecting weight or energy intake/energy expenditure in the last 6 months, including weight loss medications, antipsychotic drugs or other medications as determined by the study physician; 12. Currently participating in weight loss programs or weight change in the past 3 months (\> 5% current body weight) ; 13. Women who are pregnant or plan to become pregnant; 14. Patients who cannot be followed for 24 months (due to a health situation or migration); 15. Patients who are unwilling or unable to give informed consent.