Quantification of Cannabinoids and Comparison to Post-Surgical Pain Medication Requirements and Surgical Outcomes

University of Colorado, Denver68 enrolled

Overview

To determine how daily cannabis use affects surgical outcomes.

To determine if patients who are daily cannabis users that are undergoing inpatient abdominal surgery for the treatment of cancer are different from non-cannabis users regarding phytocannabinoid and endocannabinoid levels, pain scores, pain medication requirements, and surgical complications.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Post-Surgical Pain Post-Surgical Complication Cancer Cannabis Use

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients \> 18 years old * Undergoing abdominal surgery for the treatment of cancer * Report no cannabis use in the last year or chronic cannabis use (defined as at least weekly use for 3 months or more) Exclusion Criteria: * patients with chronic pain, chronic pain syndrome on opioids * female patients who are pregnant or lactating * patients who report use of illicit substances

Locations (1)

University of Colorado Hospital

Denver, Colorado, United States

Outcomes

Primary Outcomes

Postoperative opioid consumption

Postoperative opioid consumption among daily cannabis using and non-cannabis using patients undergoing abdominal surgery for cancer

Time frame: 30 days

Correlation of postoperative opioid consumption

Correlation between serum phytocannabinoid and endocannabinoid levels, pain scores, and postoperative opioid consumption

Time frame: 30 days

Correlation of postoperative complications

Correlation between 30-day post-operative complications, preoperative, and postoperative phytocannabinoid and endocannabinoid levels

Time frame: 30 days

Data from ClinicalTrials.gov

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