Study of the Composition and Bacterial Diversity of the Vaginal Microbiota in Healthy Versus Pathological Conditions (Bacterial Vaginosis) Using a Targeted Metagenomic Approach (RNA 16s)

Inclusion Criteria: * Woman aged between ≥ 18 and ≤ 45 years old, * In good general health (outside the gynaecological sphere), i.e. no chronic pathology and not taking medication at the time of inclusion and/or long-term, * Woman with a healthy or pathological vaginal flora according to Amsel's clinical diagnosis and Nugent's score : Population with bacterial vaginosis (verification of at least the following 3 criteria + Nugent score): * Vaginal pH \> 4.5 * greyish, homogenous vaginal secretions adhering to the vaginal wall * characteristic vaginal odour of "rotten fish" after contact of the vaginal discharge with a few drops of 10% potash ("sniff test") * Presence of "Clue Cells" in the microscopic examination of fresh vaginal secretions. Clue cells are cells of the ectocervix lined with gram-negative bacilli. * Nugent Score ≥ 7 Healthy population (Verification of at least 3 following criteria + Nugent score) : * Absence of vaginal pH \> 4.5 * No greyish, homogenous vaginal secretions adhering to the vaginal wall * No characteristic vaginal odour of "rotten fish" after contact of the vaginal discharge with a few drops of 10% potash ("sniff test"). * Absence of "Clue Cells" on microscopic examination of fresh vaginal secretions. Clue cells" are cells of the ectocervix lined with gram-negative bacilli. * Nugent Score ≤3 * Able and willing to participate in the research by complying with the procedures of the protocol, especially regarding vaginal sampling, * Having given its free, informed and written consent. Exclusion Criteria: * Patient during menstruation, * Patient who has had vaginal sex within 48 hours, * Patient with irregular menstrual cycles, * Patient undergoing preventive or curative treatment for vaginal infections, * Patients suffering from other diseases of the vagina (herpes, chlamydia, syphillis), * Patients undergoing antibiotic or antifungal treatments or taken less than 3 months ago, * Patient under probiotic or prebiotic complementation or taken less than a month ago, * Patient with systemic or immunodeficient disease, * Patient with an alcohol consumption of more than 2 glasses per day, * Pregnant or breastfeeding woman, or woman planning to become pregnant within the next 8 weeks, or woman in the post-partum period, * Patient unable to understand information related to the study (mental or linguistic disability), * Patient participating or having participated within the previous 3 months in another clinical trial, or in a period of exclusion from a clinical trial, * Patient not affiliated to a social security scheme.