This study aimed to evaluate the effects of intradialyic exercise on dialytic parameters, HRQL, and depression status in hemodialysis patients. A randomized controlled trial was conducted. Sixty-four participants were recruited using stratified random sampling and allocated with a 1:1 randomization ratio to either experimental group (EG, treated in odd weekdays, n = 32) or comparison group (CG, treated in even weekdays, n = 32). The EG received a 12-week intradialytic exercise, while the CG maintained usual lifestyles. Dialytic parameters, HRQL, and depression status were collected at baseline and at 12 weeks. The results indicated that there were no differences in changes of dialytic parameters from baseline between EG and CG. However, the EG had increased HRQL and reduced depression status at 12 weeks compared with the CG. A 12-week intradialytic exercise is safe, feasible and effective in improved HRQL and reduced depression status for hemodialysis patients.
Exercise has been shown to be of fundamental importance in managing chronic diseases and improving health-related quality of life (HRQL) as well as psychological health. However, whether intradialyic exercise is safe and has positive impact on HRQL and depression status in hemodialysis patients requires further researches with diverse racial and cultural groups to clarify. This study aimed to evaluate the effects of intradialyic exercise on dialytic parameters, HRQL, and depression status in hemodialysis patients. A randomized controlled trial was conducted at a medical center in Northern Taiwan. Sixty-four participants from 112 eligible hemodialysis patients were recruited using stratified random sampling and allocated with a 1:1 randomization ratio to either experimental group (EG, treated in odd weekdays, n = 32) or comparison group (CG, treated in even weekdays, n = 32). The EG received a 12-week intradialytic exercise (supine lower-limb ergometer, 30 minutes/session, 3 sessions/week), while the CG maintained usual lifestyles. Dialytic parameters (serum chemistries, serum electrolytes, and estimated glomerular filtration rate), HRQL, and depression status were collected at baseline and at 12 weeks. The results indicated that there were no differences in changes of dialytic parameters from baseline between EG and CG. However, the EG had increased HRQL (ß = 22.6, p\<.001) and reduced depression status (ß = -7.5, p = .02) at 12 weeks compared with the CG. A 12-week intradialytic exercise is safe, feasible and effective in improved HRQL and reduced depression status for hemodialysis patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
64
a 12-week intradialytic exercise (supine lower-limb ergometer, 30 minutes/session, 3 sessions/week)
Chia-Huei Lin
Taipei, Hawaii, Taiwan
Dialytic parameters: red blood cell [count/ul]
red blood cell \[count/ul\]
Time frame: Change from baseline red blood cell [count/ul] assessed by blood analysis at 12 weeks
Dialytic parameters: hemoglobin [g/dl]
hemoglobin \[g/dl\]
Time frame: Change from baseline hemoglobin [g/dl] assessed by blood analysis at 12 weeks
Dialytic parameters: hematocrit [%]
hematocrit \[%\]
Time frame: Change from baseline hematocrit [%] assessed by blood analysis at 12 weeks
Dialytic parameters: mean corpuscular volume [fl]
mean corpuscular volume \[fl\]
Time frame: Change from baseline mean corpuscular volume [fl] assessed by blood analysis at 12 weeks
Dialytic parameters: albumin [g/dl]
albumin \[g/dl\]
Time frame: Change from baseline albumin [g/dl] assessed by blood analysis at 12 weeks
Dialytic parameters: GPT [IU/l]
GPT \[IU/l\]
Time frame: Change from baseline [IU/l] assessed by blood analysis at 12 weeks
Dialytic parameters: GOT [IU/l]
GOT \[IU/l\]
Time frame: Change from baseline GOT [IU/l] assessed by blood analysis at 12 weeks
Dialytic parameters: blood urea nitrogen [BUN, mg/dl]
blood urea nitrogen \[BUN, mg/dl\]
Time frame: Change from baseline blood urea nitrogen [BUN, mg/dl] assessed by blood analysis at 12 weeks
Dialytic parameters: creatinine [Cr, mg/dl])
creatinine \[Cr, mg/dl\])
Time frame: Change from baseline creatinine [Cr, mg/dl]) assessed by blood analysis at 12 weeks
Dialytic parameters: sodium [Na, mEq/l]
sodium \[Na, mEq/l\]
Time frame: Change from baseline sodium [Na, mEq/l] assessed by blood analysis at 12 weeks
Dialytic parameters: potassium [K, mEq/l]
potassium \[K, mEq/l\]
Time frame: Change from baseline potassium [K, mEq/l] assessed by blood analysis at 12 weeks
Dialytic parameters: calcium [Ca, mg/dl]
calcium \[Ca, mg/dl\]
Time frame: Change from baseline calcium [Ca, mg/dl] assessed by blood analysis at 12 weeks
Dialytic parameters: phosphate [P, mg/dl]
phosphate \[P, mg/dl\]
Time frame: Change from baseline phosphate [P, mg/dl] assessed by blood analysis at 12 weeks
Dialytic parameters: IPTH [pg/ml]
IPTH \[pg/ml\]
Time frame: Change from baseline IPTH [pg/ml] assessed by blood analysis at 12 weeks
Dialytic parameters: estimated GFR [ml/min1.73m2])
estimated GFR \[ml/min1.73m2\])
Time frame: Change from baseline estimated GFR [ml/min1.73m2]) assessed by estimation based on serum creatinine at 12 weeks
health-related quality of life assessed by the scale of SF-36
self-reported health-related quality of life
Time frame: Change from baseline health-related quality of life at 12 weeks
depression status assessed by the scale of Beck Depression inventory
self-reported depression status
Time frame: Change from baseline depression status at 12 weeks
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