The goal of this study is to test the impact of diet on sleep and cardiovascular disease risk factors.
Poor sleep quality is highly prevalent in adults in the U.S. and worldwide. Recent work suggests that dietary intakes may influence sleep. This mechanistic study will test whether consuming a healthy, Mediterranean diet will improve sleep quality in U.S. adults with poor sleep and lead to better cardiovascular disease risk profile. Given the relationship between sleep and cardiovascular health, improving sleep quality through dietary measures could contribute to improving health in adults.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
11
Participants will follow specified diet requirements. Macronutrient targets for the AAD will be approximately 35-37% of energy from fat (13.5% from saturated fat), 15% from protein, and 48-50% from carbohydrates (10 g fiber/d for an average 2000 kcal/d diet).
Participants will follow specified diet requirements. Macronutrient targets for the Mediterranean diet will be approximately 40% of energy from fat (8.5% from saturated fat), 20% of energy from protein, and 40% from carbohydrates (40 g fiber/d for an average 2000 kcal/d diet).
Columbia University Irving Medical Center
New York, New York, United States
Score on the Pittsburgh Sleep Quality Index (PSQI)
The 19 questions which compose this survey assess sleep quality, latency, duration, habitual sleep efficiency, sleep disturbances, medication use and daytime dysfunction. Scores range 0 (minimum) to 21 (maximum) with \>5 indicating poor sleep quality so a lower score is a better outcome.
Time frame: 4 weeks
Sleep Fragmentation Index
Sleep Fragmentation is an index of restlessness during the sleep period expressed as a percentage (0 to 100%). The higher the index, the more sleep is disrupted.
Time frame: 4 weeks
Average Sleep Duration Per Night
Sleep duration will be actigraphy-derived.
Time frame: 4 weeks
Change in Urinary 6-sulfatoxymelatonin Level
Urinary 6-sulfatoxymelatonin will be measured by competitive ELISA and urine creatinine by clinical chemistry analyzer.
Time frame: Change from baseline to 4 weeks
Change in Tryptophan
Tryptophan metabolism
Time frame: Change from baseline to 4 weeks
Change in Kynurenine
Tryptophan metabolism
Time frame: Change from baseline to 4 weeks
Change in Serotonin
Neurotransmitter
Time frame: Change from baseline to 4 weeks
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