Brain-based Understanding of Individual Language Differences After Stroke

N/AActive Not RecruitingNCT04991519

Georgetown University400 enrolled

Overview

Strokes often cause a loss of communication ability, referred to as aphasia, as well as cognitive difficulties. Each stroke survivor has a unique pattern of strengths and weaknesses in communication and cognition, and a unique course of recovery. The BUILD study aims to understand the brain basis of these individual differences in stroke outcome. Participants with stroke as well as controls matched in age, educational background, race, and sex are examined using a combination of standardized and in-house tests of language and cognition to provide a detailed profile of strengths and weaknesses. Each participant will have between three and six sessions, including an MRI to measure details of the structure, function, and connections in the brain. The data are analyzed to test how patterns in the stroke lesion explain the patterns of communication and cognitive difficulties, and how patterns in the uninjured parts of the brain explain resilience and recovery from the stroke. Ultimately, we hope that BUILD will guide us toward new targets for brain stimulation treatments or other biologically based treatments that improve language and cognitive abilities after stroke.

Study Type

OBSERVATIONAL

Enrollment

400

Conditions

Aphasia Stroke Alexia

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Stroke Survivors: * Age \>=18 * Stroke in left hemisphere of brain with or without aphasia, or stroke elsewhere causing aphasia * Learned English at 8 years or younger Controls: * Age \>=18 * No history of brain injury resulting from stroke, trauma, infection (i.e. encephalitis), or tumor * Learned English at 8 years or younger Exclusion Criteria: * History of other brain conditions that could impact interpretation of results (such as multiple sclerosis, premorbid dementia) * Severe psychiatric condition that would interfere with participation in the study * History of a learning disability that could impact interpretation of results Additional Exclusion Criteria for MRIs: * Pacemaker or magnetic metal in the body that is not MRI compatible * Pregnancy * Claustrophobia

Outcomes

Primary Outcomes

MP-RAGE (Magnetization Prepared Rapid Acquisition Gradient Echo)

Part of MRI sequence that measures deep grey matter structure.

Time frame: Collected within 1 month of behavioral testing

DTI (Diffusion Tensor Imaging)

Part of MRI sequence that measures the rate of water diffusion between cells to understand and create a map of internal structures.

Time frame: Collected within 1 month of behavioral testing

Behavioral testing

Battery of standard clinical and in-house behavioral tests to measure speech, language, and cognition. Final score is derived from principle components analysis.

Time frame: Collected within 1 month of MRI