Effect of Sweetness Intensity of a Sucrose Solution on Blood Glucose Regulation and Energy Intake

Early Phase 1CompletedNCT04991714

University of Vienna30 enrolled

Overview

The aim of the present study is to investigate the influence of the modulation of the sweetness intensity of a carbohydrate (sucrose)-containing solution on metabolic effects, in particular the regulation of blood glucose concentration and regulation of hunger \& satiety.

The study is designed as a randomised cross-over intervention study with four interventions. The study investigates the influence of sweetness modulation by Rebaudioside M (sweetness enhancement) and Lactisol (sweetness inhibition) of a 10% sucrose solution, corresponding to the concentration of a regular soft drink, on blood glucose regulation (blood glucose concentration and regulating hormones) in healthy male volunteers. Furthermore, the study assesses ad libitum energy intake, individual feelings of hunger and satiety, metabolic responses to the interventions, and preference for sweet-tasting foods such as sugar and sweeteners. In addition, the participants' individual thresholds for sweet taste, as well as morphological markers for taste sensitivity and body composition will be recorded as potential influencing factors.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Blood Glucose, Low Hunger

Interventions

LactisoleDRUG

sweet taste inhibitor (decreases sweetness)

Rebaudioside MDRUG

Sweetener (increases sweetness)

SucroseOTHER

10% Sucrose corresponding to a regular soft drink

Eligibility

Sex: MALEMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * male * healthy * non-smoking * normal taste responses towards sweet taste Exclusion Criteria: * female * regular smokers * disturbed glucose and/or lipid metabolism * regular intake of medication * known allergies against one of the test compounds * ageusia * alcohol or drug addiction * intake of antibiotics within the past 2 months

Locations (1)

Christian Doppler Laboratory for Taste Research

Vienna, Austria

Outcomes

Primary Outcomes

Blood glucose concentration

Glucose concentration \[mg/dL\] in plasma samples before, and 15, 30, 60, 90, and 120 minutes after drinking the test solution

Time frame: over a time span of 120 minutes after drinking the test solution

Insulin concentration

Insulin concentration \[mmol/L\] in plasma samples before, and 15, 30, 60, 90, and 120 minutes after drinking the test solution

Time frame: over a time span of 120 minutes after drinking the test solution

GLP-1 concentration

Glucagon-like peptide 1 concentration in plasma samples \[mmol/L\] before, and 15, 30, 60, 90, and 120 minutes after drinking the test solution

Time frame: over a time span of 120 minutes after drinking the test solution

GIP-concentration

Gastric inhibitory polypeptide concentration in plasma samples \[mmol/L\] before, and 15, 30, 60, 90, and 120 minutes after drinking the test solution

Time frame: over a time span of 120 minutes after drinking the test solution

Secondary Outcomes

Food intake

Ad libitum Food intake from a standardized breakfast

Time frame: 120 minutes after drinking of the test solution

Metabolic changes

Metabolome analysis in plasma samples \[mmol/L\] before, and 15, 30, 60, 90, and 120 minutes after drinking the test solution

Time frame: over a time span of 120 minutes after drinking the test solution

Data from ClinicalTrials.gov

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