Analysis of the Molecular Profile of the Mixofibrosarcoma of the Extremities

Istituto Ortopedico Rizzoli167 enrolled

Overview

Single institution case series review with a histological diagnosis of mixofibrosarcoma of the extremities from 01 Jan 1993 to 01 Dec 2017. The study will exam all the clinical, radiological, histological and immunohistochemical features of this tumour in all samples and in a limited serie of cases the presence of mutation of 50 genes cancer related.

Study Type

OBSERVATIONAL

Enrollment

167

Conditions

Sarcoma,Soft Tissue

Interventions

case series review of clinical and histological dataOTHER

We will review all the medical records, radiological imaging, and histological data of these cases. The immunohistochemical analysis of the principal alterated genes identified in this tumor will be performed.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Male and female patients treated at Rizzoli Institute from 01 Jan 1993 to 01 Dec 2017 2. Diagnosis of mixofibrosarcoma of extremities 3. Histological slides/formalin-fixed paraffin-embedded tissue tumor (FFPE) blocks from archive available to perform the histology analysis and molecular analysis 4. Enough tumor biobanked material available for molecular analysis 5. Presence of the biobank signed informed consent 6. Written informed consent prior to any study-specific analysis and/or data collection Exclusion Criteria: 1\) Patients with histological diagnosis different from mixofibrosarcoma of extremities

Locations (1)

Istituto Ortopedico Rizzoli

Bologna, BO, Italy

Outcomes

Primary Outcomes

disease-free survival

identify patients with different risk classes in terms of disease-free survival (local and systemic recurrence).

Time frame: at baseline (Day0)

overall survival

identify patients with different risk classes in terms of overall survival.

Time frame: at baseline (Day0)

Data from ClinicalTrials.gov

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