Impact of Total Intravenous Anesthesia Following Cancer Surgery, TIVACS Study

Inclusion Criteria: * Adults: ≥18 years old on the day of consent * Non-metastatic pancreatic adenocarcinoma * Able to provide consent * ECOG performance status of 0 or 1 * Women of childbearing potential (WOCBP) must have a negative urine or serum pregnancy test for the patient at the time of surgery. * Ability to understand and the willingness to sign a written informed consent document. Exclusion Criteria: * Previous identified allergy or hypersensitivity to any component of the study treatment * Allergies to eggs, egg products, soybeans, or soy products * Personal or first degree relative with a history of malignant hyperthermia * Has a known additional malignancy that is expected to require active treatment within two years, or is likely to be life-limiting in the opinion of the treating investigator. Superficial bladder cancer, non-melanoma skin cancers, or low-grade prostate cancer not requiring therapy would not exclude participation in this trial. * Uncontrolled intercurrent illness including, but not limited to: Symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements. * Pregnant or lactating females * Major surgery within 2 months before enrollment. Complete healing from major surgery must have occurred 1 month before enrollment. Complete healing from minor surgery (eg, simple excision, tooth extraction) must have occurred at least 7 days before enrollment. Subjects with clinically relevant complications from prior surgery are not eligible. * Patients who undergo reoperation during their initial hospitalization will be censored at the time of reoperation. * Prisoner status