Endoscopic Resection of Early Esophageal Tumors in the Context of Cirrhosis or Portal Hypertension

Central Hospital, Nancy, France112 enrolled

Overview

Cirrhotic patients may be at high risk for esophageal cancer. Endoscopic resection is the standard treatment for superficial tumors. However, cirrhosis might be associated with upper gastrointestinal bleeding, particularly in case of portal hypertension or coagulopathy. This study aims to assess safety, efficacy and methods to prevent potential complications in cirrhosis or portal hypertension context for esophageal endoscopic resection. This retrospective multicentric French-Belgian study includes all consecutive patients with cirrhosis or portal hypertension who underwent esophageal endoscopic resection from January 2005 to 2021.

Study Type

OBSERVATIONAL

Enrollment

112

Conditions

Esophageal Neoplasms Cirrhosis Portal Hypertension

Interventions

Endosocpic resection of early esophageal tumor

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * older than 18 years with cirrhosis or portal hypertension who underwent endoscopic resection of an early esophageal tumor Exclusion Criteria: * younger than 18

Outcomes

Primary Outcomes

technical success of early esophageal cancer resection

defined by a complete macroscopic resection

Time frame: baseline

Secondary Outcomes

adverse events per procedure (immediate bleeding, perforation)

Time frame: baseline

morbidity post procedure (delayed bleeding, infection, esophageal stenosis, 30-days related liver decompensation, 30-days related mortality)

Time frame: up to 4 weeks

Potential risk factors for adverse events

Time frame: baseline

preemptive methods to the risk of bleeding

Time frame: baseline