Apparently healthy and well-functioning community dwelling 70-80 year-olds will be recruited to the study. All subjects undergo pre-screening for suitability and a physicians examination, as well as 7-day habitual daily steps are measured to ascertain baseline physical activity. Half of the recruited subjects (n=40) will be randomized into the intervention group and half (n=40) randomized into the control group. The intervention group is then required to reduce their daily steps to \<2000 for a 2-week period. Thereafter, the intervention group participates to a 4-week strength+endurance training rehabilitation program and no longer has restricted daily step count. The control group continues their normal habitual physical activity level throughout the 6-week study period.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
66
2-week limited daily steps (\<2000), and then 4 weeks of typical strength+endurance exercise for older adults
University of Jyväskylä
Jyväskylä, Central Finland, Finland
Lean leg mass
DXA-measured total lean mass of the legs
Time frame: 6 weeks
Whole-body fat mass
DXA-measured total body fat mass
Time frame: 6 weeks
Maximum isometric leg extension force
Maximum strength of legs
Time frame: 6 weeks
Walking economy
Oxygen uptake while walking at 3 and 5 km.h-1
Time frame: 6 weeks
Short Physical Performance Battery (SPPB)
Walking, balance and chair-rise tests
Time frame: 6 weeks
Blood pressure
Systolic and diastolic blood pressure during rest (sitting)
Time frame: 6 weeks
HOMA indices
Blood glucose and insulin concentration based calculations related to insulin resistance and beta-cell function
Time frame: 6 weeks
White blood cell respiration
Isolated white blood cell respiration as a marker for mitochondrial function
Time frame: 6 weeks
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