The aim of the present study is to investigate serum estradiol and progesterone levels in women conceiving after natural, estradiol + progesterone or gonadotropin stimulated frozen embryo transfer (FET) cycles.
Enrolled women will be randomized based on their ovulation pattern. Ovulatory women will be randomized to either natural cycle or estradiol + progesterone substituted cycle treatment for FET. Anovulatory women will be randomized to either estradiol + progesterone substituted cycle or gonadotropin stimulated cycle treatment for FET. Included women will undergo blood testing every two weeks for serum estradiol and progesterone levels until gestational age 9+6. Routine vaginal ultrasounds will be performed as well as additional pregnancy ultrasounds. Secondary obstetric outcomes will be investigated using the womens medical journals. All the treatments are considered standard treatments for FET.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Enrollment
305
Combined with progesterone
Combined with estradiol
Combined with hCG
Herlev University Hospital
Herlev, Denmark
Serum estradiol
Blood samples in the first 10 weeks of pregnancy
Time frame: 10 weeks
Serum progesterone
Blood samples in the first 10 weeks of pregnancy
Time frame: 10 weeks
Gestational age at delivery
Weeks of pregnancy when the child has been delivered
Time frame: At delivery
Child birth weight
Weight of the child at delivery
Time frame: At delivery
Obstetric complications
Obsteric complication throughout pregnancy
Time frame: 9 months
Child malformations
Child malformations diagnosed in utero or at delivery
Time frame: 9 months
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In either natural cycle or combined with Follitropin Alfa