The research is designed to study the prognostic factors of ventriculoperitoneal (VP) shunt for iNPH by multi-omics research
Preoperative T1-MRI, functional MRI and diffusion MRI imaging data of iNPH patients were collected. The clinical assessment was performed before/after the lumbar puncture test and 6 months after VP shunt. Clinical assessment included Mini-mental State Examination (MMSE), gait scores, Kiefer score, and Modified Rankin Scale (mRS). The cerebrospinal fluid was collected by tap-test, and 6 months after surgery by puncturing in the VP device pump. Methods- The primary methods used are: 1. The cerebrospinal fluid proteomic analysis of iNPH patients before and after VP shunt surgery. 2. The structral and functional MRI analysis of iNPH patients 3. The clinical assessment of MMSE, gait scores, Kiefer score, and mRS. Objective- To study the prognostic factors of VP shunt for iNPH.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
40
A ventriculoperitoneal shunt is a tube that drains excess cerebrospinal fluid into abdomen
The second affliated hospital of zhejiang university
Hangzhou, Zhejiang, China
RECRUITINGProteomic pattern of CSF in iNPH patients
Comparing the proteomic pattern differences in CSF between iNPH patients and normal age-matched normal volunteers by the analysis of mass spectrometry. Also, the responsive and non-responsive iNPH patients proteomic pattern were analzed.
Time frame: Before surgery in lumbar CSF
Proteomic pattern changes of CSF in iNPH patients after VP shunt
Comparing the proteomic pattern differences in CSF of iNPH patients before surgery and after VP shunt by the analysis of mass spectrometry. Also, the responsive and non-responsive iNPH patients proteomic pattern were analzed.
Time frame: Change from Baseline (ventricular CSF) at 6 months after VP shunt
Gray Matter Density
Using automatic cortical and subcortical segmentation from the 3-dimensional T1weighted images to measure gray matter density in iNPH patients before surgery compared with healthy individual group. Also, the responsive and non-responsive iNPH patients structral MRI were analzed.
Time frame: Before surgery
Change in the resting state fMRI
Change of BOLD singal intensity in the resting state fMRI in iNPH patients compared with normal healthy group. Also, the responsive and non-responsive iNPH patients functional MRI were analzed.
Time frame: Before surgery
White matter abnormity
Franctional anisotropy, mean diffusivity and apparent diffusion coefficient were measured by diffusion MRI in region of interest of iNPH patients compared with normal healthy group. Also, the responsive and non-responsive iNPH patients diffusion MRI were analzed.
Time frame: Beore surgery
Kiefer score
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
A score for iNPH severity; range 0-26; higher indicates higher severity.
Time frame: Change from Baseline at 6 months after VP shunt
Mini mental state Examination
A score for cognitive ability; range 0-30; higher indicates higher severity.
Time frame: Change from Baseline at 6 months after VP shunt
Gait evaluation
10 meters walking test were evaluated of iNPH patients.
Time frame: Change from Baseline at 6 months after VP shunt
modified Rankin scale
A score for functional neurological status ; range 0-5; higher indicates higher severity.
Time frame: Change from Baseline at 6 months after VP shunt