Effects of Curcumin-containing Toothpaste on Dental Biofilm and Associated Oral Halitosis

Inclusion Criteria * Participants must be adult males or females between the ages of 18 and 65 years (inclusive) reporting halitosis * Participants must be able and willing to follow study procedures and instructions * Participants must have read, understood and signed an informed consent form * Participants must present with at least 8 teeth in the functional dentition and with at least 4 teeth in each posterior sextant, 3 of which are adjacent teeth with interproximal papilla in each posterior sextant that will have the stent * Participants must be in good general health Exclusion Criteria * Patients ongoing restorative or periodontal dental treatment or any other medical treatment * Subjects with any pathological alterations of the oral mucosa * Any known allergy to previously used oral hygiene products or any known allergy to any of the ingredients of the study products, which are used during the study * Pregnant women * Subjects with untreated periodontitis or active caries lesion * Subjects diagnosed with acute sinusitis, bronchitis or tonsillitis * Subjects under treatment on medications which can cause malodor, e.g. amphetamines, nitrates and nitrites * Known diabetes, liver or kidney insufficiency * Subjects diagnosed with reduced salivary flow due to pathological reasons (e.g. Sjögren syndrome) * Subjects who underwent preventive periodontal treatment, i.e. oral prophylaxis treatment, within the last week * Volunteers unwilling to abstain from additional oral hygiene (only tooth brushing allowed) particularly mouthrinse, chewing gums, breath strips, etc and alcohol 12 h prior the first measurement at the study site and until the completion of all measurements