Lung Volume Perception and Impact of a Cognitive Task on Ventilation in Hypermobile Ehlers-Danlos Syndrome.

Hakimi Adrien38 enrolled

Overview

Patients with hypermobile Ehlers-Danlos syndrome have respiratory and proprioceptive disorders. The aim of this study is to explore whether there is an alteration in lung volume perception in patients with hEDS compared to healthy subjects, and whether a cognitive task can influence ventilation control differently in subjects with hEDS than in healthy subjects.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Hypermobile Ehlers-Danlos Syndrome

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria (common): * More than 18 years old * Understanding French Inclusion Criteria (hEDS Patients): * hEDS diagnosis Inclusion Criteria (healthy subjects): * Age (±5 years), Gender and BMI (±2.5kg/m²) matching Exclusion Criteria (common): * Pregnancy Exclusion Criteria (hEDS Patients): * Respiratory comorbidity independent of hEDS * Previous participation in a rehabilitation programme at the clinic Exclusion Criteria (healthy subjects): * Known respiratory or proprioceptive pathology * Hypermobility (evaluated with the Beighton score)

Locations (1)

Clinique de la Mitterie

Lomme, France

Outcomes

Primary Outcomes

Accuracy of lung volume perception

The perception of lung volume is assessed using a device comprising a flow meter, an electronic acquisition card and an LCD screen. Subjects will be given 3 trials to train to perceive a target lung volume and then 3 trials without feedback to reproduce that target lung volume. The mean of the absolute deviations from the target volumes in percent is used as the primary outcome.

Time frame: Baseline

Secondary Outcomes

Minute ventilation with or without cognitive task

The minute ventilation will be calculated over 1 minute without cognitive task and then over 1 minute with cognitive task (trail making test part B).

Time frame: Baseline

Respiratory rate variability

The time interval between each inspiratory peak will be recorded and will allow the calculation of the standard deviation and the root mean square with and without the cognitive task.

Time frame: Baseline

Data from ClinicalTrials.gov

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