Umbilical cord blood mononuclear cells contain hematopoietic stem cells (HSC), mesenchymal stem cells (MSC), endothelial progenitor cells and other pluripotent stem cells, as well as immature immune cells, which can differentiate into chondrocytes, hematopoietic, epithelial, endothelial and nerve cells. It gives the ability to promote wound healing and vascular microcirculation reconstruction, and has the potential to treat many diseasesHowever, clinical studies on cord blood mononuclear cells in knee osteoarthritis have not been reported in the literature. Therefore, this study aims to explore the safety and effectiveness of cord blood mononuclear cells in the treatment of patients with knee osteoarthritis.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
30
Intra-articular injection of normal saline
Intra-articular injection of Cord Blood Mononuclear Cells (UCB-MNCs)
Qianfoshan Hospital
Jinan, Shandong, China
Lysholm score
Evaluation of functional perception of daily activities and motor function levels of different intensities.The score ranges from 0 to 100 points, the lower the score, the more severe the knee joint damage.
Time frame: Compare the changes of 1 month, 3 months, 6 months and one year before treatment (baseline) and after (third injection)
American knee society knee score
Evaluation of the overall function and shape of the knee joint.The score ranges from 0 to 100 points. The lower the score, the worse the knee joint function.
Time frame: Compare the changes of 1 month, 3 months, 6 months and one year before treatment (baseline) and after (third injection)
the knee injury and osteoarthritis score
A questionnaire for evaluating the effectiveness of knee joint injury and osteoarthropathy treatment based on patient self-assessment management.The KOOS score consists of five parts, and each part contains a different number of questions. Each question has a minimum of 0 points and a maximum of 4 points. After the score of each part is calculated separately, it is converted into a percentile score through the conversion formula. A score of 0 in the converted percentile score means that the function of that part of the joint is extremely poor, and a score of 100 means that the function of this part of the joint is completely normal.
Time frame: Compare the changes of 1 month, 3 months, 6 months and one year before treatment (baseline) and after (third injection)
Visual Analog Score for pain
Physicians Global Assessment to measure quality of life.The score ranges from 0 to 10 points, the lower the score, the more severe the pain.
Time frame: Compare the changes of 1 month, 3 months, 6 months and one year before treatment (baseline) and after (third injection)
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