Cognitive Functioning in Opioid Use Disorder

New York State Psychiatric Institute13 enrolled

Overview

This outpatient study is designed to examine the potential relationship between non-fatal opioid overdose and cognitive functioning. This study will also examine the impact of computerized working memory training on relevant outcomes (cognition, psychosocial functioning, quality of life, drug use). The training component of the study lasts 1 month, with follow up visits and 1-month and 3-months post training.

This outpatient study is designed to examine the potential relationship between non-fatal opioid overdose (i.e. overdose that does not result in death), cognitive functioning, and the impact of computerized working memory training on relevant outcomes (cognition, psychosocial functioning, quality of life). Participants (n=30) with a history of at least one prior opioid OD, who are enrolled in buprenorphine treatment, will be randomized to 20 sessions of an active (n=15) or sham (n=15) working memory training. Patients will complete measures of cognitive functioning during screening, post-training, and at 1-month and 3-month follow up. Participants will also complete the measures of decision making, psychosocial functioning and drug use at baseline, post-training, and follow up.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Opioid Use Cognitive Change Opioid-use Disorder

Interventions

CogMedOTHER

20 sessions of Cogmed working memory training

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Meets DSM-5 criteria for moderate-severe Opioid Use Disorder (OUD) in the past 6 months * Enrolled in a suboxone (buprenorphine/naloxone) program; willing to provide consent for research team to contact treatment provider * History of at least 1 prior opioid overdose * Recent history of illicit opioid use * In good physical health * Access to a smartphone, tablet, or computer Exclusion Criteria: * Evidence of a co-occurring, untreated psychiatric condition that would make participation risky or difficulty * Lack of access to a home computer, smartphone, or tablet * Unable to speak, read and/or communicate in English

Locations (1)

NY State Psychiatric Institute

New York, New York, United States

Outcomes

Primary Outcomes

NIH Toolbox Cognition Battery

A brief computerized test of key neuropsychological functions

Time frame: Post-Training (1-month from baseline)

NIH Toolbox Cognition Battery

A brief computerized test of key neuropsychological functions

Time frame: 1-month Follow up

NIH Toolbox Cognition Battery

A brief computerized test of key neuropsychological functions

Time frame: 3-month Follow up

Secondary Outcomes

Psychosocial Functioning (Brief Inventory of Psychosocial Functioning B-IPF)

B-IPF: scores range from 0 to 49 with higher scores indicating greater difficulties with psychosocial functioning

Time frame: Post-training (1 month from baseline)

Psychosocial Functioning (Brief Inventory of Psychosocial Functioning B-IPF)

B-IPF: scores range from 0 to 49 with higher scores indicating greater difficulties with psychosocial functioning

Time frame: 1-month follow up

Psychosocial Functioning (Brief Inventory of Psychosocial Functioning B-IPF)

B-IPF: scores range from 0 to 49 with higher scores indicating greater difficulties with psychosocial functioning

Time frame: 3-month follow up

Illicit Substance Use: Timeline Follow Back (TLFB)

TLFB: measures substance use in the past 1-week period

Time frame: Post-training (1-month from baseline)

Data from ClinicalTrials.gov

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