Renal Failure Following Lung Transplantation in Cystic Fibrosis Patients

Policlinico Hospital85 enrolled

Overview

With this retrospective observational cohort study, we performed a longitudinal assessment of the renal function of the adult CF patients who underwent LUTX, aiming 1) to describe possible risk factors associated with perioperative AKI and 2) to describe AKI short and long term effects on clinical outcomes.

This study is a retrospective analysis of prospectively collected data from medical records of all consecutive CF patients who underwent LUTX at our Institution from January 2013 to December 2018.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cystic Fibrosis

Interventions

Lung TransplantationPROCEDURE

Double lung transplant

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All patients with CF who underwent LUTX during the study period were considered. Exclusion Criteria: * single LUTX * re-transplantation * missing medical records; * age \< 18 years old

Locations (1)

Fondazione IRCCS Ca'Granda - Ospedale Maggiore Policlinico

Milan, Italy

Outcomes

Primary Outcomes

Acute Kidney Injury

AKI stage 1, stage 2, and stage 3 whether a 1.5-1.9 times, 2-2.9 times, and \>3 times increase from the preoperative creatinine was measured, respectively. Following KIDGO criteria

Time frame: 1 month

Secondary Outcomes

Survival

Death at follow-up

Time frame: Until May 31 2021

Data from ClinicalTrials.gov

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