Thalamic Nuclei Volumes in Multiple Sclerosis

University Hospital, Bordeaux2,000 enrolled

Overview

The thalamus is composed of several nuclei interlocked in a complex anatomy. In multiple sclerosis (MS), the thalamus can be altered due to disconnection by white matter lesions and due to direct damages that could be partly mediated by CSF. Due to such pathophysiology and complex anatomy, some nuclei could be more vulnerable to multiple sclerosis than others. We will test this hypothesis by using a new algorithm to automatically segment several nuclei that we will be applied to the French national MS database

Study Type

OBSERVATIONAL

Enrollment

2,000

Conditions

Multiple Sclerosis

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria : * Patient older than 18 years old. * With Multiple Sclerosis according to Mc Donald 2017 criteria or with clinically isolated syndrome and included with OFSEP cohort. * Phenotype known (RR, SP, PP or CIS). * Date of diagnosis known. * With at least one MRI that includes 3D T1 and FLAIR at 1.5T or 3T. Exclusion Criteria : * Stroke * Other causes of dementia not caused by Multiple Sclerosis (Alzheimer's disease, Parkinsonian syndromes…)

Locations (1)

CHU Bordeaux

Bordeaux, France

RECRUITING

Outcomes

Primary Outcomes

Volume of thalamic nuclei

Volume of individual thalamic nuclei according to disease duration.

Time frame: At inclusion in the cohort

Central Contacts

Thomas Tourdias, Pr

CONTACT

05 56 79 56 04 thomas.tourdias@chu-bordeaux.fr

Data from ClinicalTrials.gov

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