The skin microbiome diversity in female healthy volunteers will be studied along with cosmetic products application in 1 month period. This study is also aimed to investigate the efficacy of cosmetic products on skin rejuvenation. .
The study is conducted in COVID-19 pandemic era, thus every person involved in this study must follow health protocol for COVID-19. The study procedure, consist of screening visit (D -7), 7-day wash out, baseline visit (D 0), first follow up ( D 14), and second follow up (D 28). 1. Screening visit: obtained Informed Consent, COVID-19 detection by swab RT-PCR, and inclusion and exclusion criteria, wash out product dispensing, and subject's diary dispensing. 2. Baseline visit: Investigator will check vital signs, facial skin value by Cutometer, Mexameter, Sebumeter, Corneometer, Colorimeter, Tewameter, dan pH meter, and kin taping by Corneofix tape. Investigational Products will dispensed in this visit for 2 weeks usage. 3. First follow up: Investigator will check vital signs and facial skin value. Investigational Products will dispensed in this visit for 2 weeks usage. 4. Second follow up: Investigator will check vital signs, facial skin value, and skin taping by Corneofix tape. All adverse events (AEs) occurred during study will be recorded in Case Report Form.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
24
Female healthy volunteers applied cosmetic products (cleanser and moisturizer) in the morning and afternoon for 1 month. Seven days wash out period will be conducted prior study starts. The evaluation will be conducted before, two weeks after treatment starts, and at the end of the study.
Clinical Research Supporting Unit
Jakarta Pusat, DKI Jakarta, Indonesia
Microbiome diversity index
The amount and diversity of microbiota will be observed on facial skin before and after product application
Time frame: 28 days
Facial skin elasticity
The ratio between pliability/firmness and expressed in mm. The result before and after product application will be observed by cutometer.
Time frame: 28 days
Sebum unit of facial skin
Sebumeter unit (mcg/cm2) of facial skin before and after product application will be observed using sebumeter. This sebumeter unit reflects the concentration of sebum on skin per observed area.
Time frame: 28 days
Capacity of corneometer unit
Corneometer unit reflects the moist index of skin. The corneometer unit observed by Corneometer, before and after product application.
Time frame: 28 days
Skin color intensity
The skin color expressed in colorimeter index value. The observation is conducted before and after product application
Time frame: 28 dyas
Transepidermal Waterloss (g/h/m2)
The hydration of skin is observed by Tewameter. The observation is conducted before and after product application
Time frame: 28 days
pH of facial skin
The pH of facial skin is observed using skin-pH-meter. Observation is conducted before and after product application
Time frame: 28 days
The skin color related to the Minimal Erythema Dosage (MED)
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The skin color (MED) is observed using Mexameter and is conducted before and after product application
Time frame: 28 Days