The aim of the study is to evaluate the effect of plasmapheresis (repeated plasma withdrawals) on selected health indicators (hematological, biochemical, immunological and indicators of biological age) of plasma donors.
Study Type
OBSERVATIONAL
Enrollment
41
Procedure whereby plasma is separated and extracted from anticoagulated whole blood and the red cells retransfused to the donor.
Charles University, Medical Faculty in Hradec Kralove
Hradec Králové, Czechia
Significant change of biological age according to epigenetic clock after 8 plasmaphereses
Significant change of the epigenetic age of the plasma donors after 8 cycles of plasmapheresis conducted or a slower increase of the biological age throughout the study than the increase of the chronological age.
Time frame: Through study completion, an average of 8 months
Significant change of biological age according to epigenetic clock after 8 plasmaphereses
Significant change of the epigenetic age of the plasma donors after 4 cycles of plasmapheresis conducted or a slower increase of the biological age throughout the study than the increase of the chronological age.
Time frame: Through study completion, an average of 8 months
Significant change of the proteomic profile after 8 plasmaphereses
Proteomic analysis showing signs of a rejuvenated proteostasis in the plasma donors after 8 cycles of plasmapheresis.
Time frame: Through study completion, an average of 8 months
Significant change of the proteomic profile after 4 plasmaphereses
Proteomic analysis showing signs of a rejuvenated proteostasis in the plasma donors after 8 cycles of plasmapheresis.
Time frame: Through study completion, an average of 8 months
Significant change of the biological age according to a blood biochemistry clock after 8 plasmaphereses
Blood biochemistry clock showing phenotype of a younger individual in the plasma donors after 8 cycles of plasmapheresis.
Time frame: Through study completion, an average of 8 months
Significant change of the biological age according to a blood biochemistry clock after 4 plasmaphereses
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Blood biochemistry clock showing phenotype of a younger individual in the plasma donors after 8 cycles of plasmapheresis.
Time frame: Through study completion, an average of 8 months