3D Craniofacial Morphologic Development of Healthy Infants

Chang Gung Memorial Hospital30 enrolled

Overview

Healthy infants were enrolled to receive three dimensional craniofacial photography regularly at their age of one month, two month, four month, six month, nine month and twelve month. All the image data was analyzed to reveal infants' craniofacial development.

Importance The development of craniofacial morphology in the first year of life is critical, especially when analyzed with longitudinal 3-dimensional photographs. Objective To evaluate the development of the craniofacial region in healthy infants in the first year of life and provide treatment guidelines for craniofacial deformities such as orofacial clefts and deformational plagiocephaly. Design, Setting, and Participants Three-dimensional (3D) photographs of included participants were captured using a 3dMD system. Participants were grouped by sex and age (1, 2, 4, 6, 9, and 12 months). We placed 32 craniofacial anatomical landmarks on 3D craniofacial photos. The thin-plate spline algorithm and closest-point matching were applied to transform a symmetric 3D template into a series of scanned images to calculate 3D composite heads at different ages. Main Outcomes and Measures Average craniofacial meshes were calculated for each group. The growth patterns of the following anthropometric indices were determined: craniofacial height, depth, width, volume, body height, weight, body mass index (BMI), and head circumference.

Study Type

INTERVENTIONAL

Allocation

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Enrollment

Conditions

Development, Infant IMAGE Craniofacial Asymmetry Plagiocephaly

Interventions

three dimensional photography using a 3dMDHead System (3dMD, Atlanta, GA, USA)OTHER

A series of 3D craniofacial photos were captured using a 3dMDHead System (3dMD, Atlanta, GA, USA) within 7 days before or after the age of 1, 2, 4, 6, 9, and 12 months.

Eligibility

Sex: ALLMin age: 1 MonthMax age: 12 MonthsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Asian ethnicity * healthy infants * full-term Exclusion Criteria: * growth curve \<3% * premature * congenital craniofacial anomaly * hormonal anomaly. * chromsomal anomaly * thyroid anomaly * bone anomaly

Locations (1)

Chang Gung Memorial Hospital

Taoyuan District, Taiwan