The aim of our study is to evaluate the effect of magnesium on the hypnotic effect of propofol.
The aim of our study is to evaluate the effect of magnesium on the hypnotic effect of propofol. To achieve this, the investigators will analyse the effect of magnesium on the brain concentrations of propofol required to achieve a State Entropy value between 50-60, which corresponds to the recommended depth of anaesthesia. Our study will also evaluate the intraoperative anti- nociceptive effect of magnesium using pupillometry and its two indices, PPI and PRD
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE
Enrollment
20
Infusion of magnesium sulphate 50 mg/kg (eq. 0.5ml/kg of magnesium sulphate 100mg/ml)
Infusion of NaCl (sodium chloride) 0.9% (placebo eq. 0.5ml/kg of NaCl 0.9%)
CHU Liege,
Liège, Belgium
Propofol target concentration
The target concentration of Propofol TCI (target-control infusion) to achieve a state entropy value between 50-60
Time frame: through study completion, an average of 3 months
Morphine consumption
Morphine consumption titrated in the recovery room and morphine equivalents claimed during the first 24 hours postoperatively
Time frame: through study completion, an average of 3 months
PPI Measure
PPI (pupillary pain index) by pupillometry with "AlgiScan®" monitoring, before endotracheal intubation and with a State Entropy of 50-60, then every 5 min between endotracheal intubation and surgical incision
Time frame: through study completion, an average of 3 months
PRD Measure
PRD (pupillary reflex dilatation) during laryngoscopy maintained for 30 sec, surgical incision and 10min after surgical incision
Time frame: through study completion, an average of 3 months
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