In multiple previous studies that have explored the use of dexmedetomidine in transsphenoidal tumor resection surgery, dexmedetomidine showed many beneficial effects like reducing the requirement of analgesics and anesthetics, improving hemodynamic stability and decreasing the emergence time, extubation time and visual analog scale at emergence. Therefore, the investigators hypothesized that dexmedetomidine would decrease neuroendocrine stress response and improve the quality of postoperative recovery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
SINGLE
Enrollment
64
Patients were randomly assigned to the dexmedetomidine or control group. Dexmedetomidine group received intravenous dexmedetomidine and control group received intravenous normal saline during surgery.
Patients were randomly assigned to the dexmedetomidine or control group. Dexmedetomidine group received intravenous dexmedetomidine and control group received intravenous normal saline during surgery.
Seoul National University Hospital
Seoul, South Korea
Quality of recovery-15 (QoR-15) score
Self-rated questionnaire composed of 15 items (each item: 0-10 points, total: 0-150 points) of five dimensions: physical well-being, physical independence, emotional state, psychological support, and pain. Higher scores indicate better quality of recovery.
Time frame: postoperative day 1
Serum level of triiodothyronine (T3)
ng/dL
Time frame: preoperative (1-2 month before surgery), intraoperative (when surgeon starts tumor resection), immediately postoperative (30 min after the end of surgery)
Serum level of triiodothyronine (T4)
ng/dL
Time frame: preoperative (1-2 month before surgery), intraoperative (when surgeon starts tumor resection), immediately postoperative (30 min after the end of surgery)
Serum level of thyroid stimulating hormone (TSH)
uIU/mL
Time frame: preoperative (1-2 month before surgery), intraoperative (when surgeon starts tumor resection), immediately postoperative (30 min after the end of surgery)
Serum level of luteinizing hormone (LH)
mIU/mL
Time frame: preoperative (1-2 month before surgery), intraoperative (when surgeon starts tumor resection), immediately postoperative (30 min after the end of surgery)
Serum level of follicle stimulating hormone (FSH)
mIU/mL
Time frame: preoperative (1-2 month before surgery), intraoperative (when surgeon starts tumor resection), immediately postoperative (30 min after the end of surgery)
Serum level of adredocorticotrophic hormone (ACTH)
pg/mL
Time frame: preoperative (1-2 month before surgery), intraoperative (when surgeon starts tumor resection), immediately postoperative (30 min after the end of surgery)
Serum level of growth hormone (GH)
ng/mL
Time frame: preoperative (1-2 month before surgery), intraoperative (when surgeon starts tumor resection), immediately postoperative (30 min after the end of surgery)
Serum level of insulin-like growth factor-1 (IGF-1)
ng/mL
Time frame: preoperative (1-2 month before surgery), intraoperative (when surgeon starts tumor resection), immediately postoperative (30 min after the end of surgery)
Serum level of prolactin
ng/mL
Time frame: preoperative (1-2 month before surgery), intraoperative (when surgeon starts tumor resection), immediately postoperative (30 min after the end of surgery)
Serum level of antidiuretic hormone (ADH)
pg/ml
Time frame: preoperative (1-2 month before surgery), intraoperative (when surgeon starts tumor resection), immediately postoperative (30 min after the end of surgery)
Serum level of cortisol
ug/dL
Time frame: preoperative (1-2 month before surgery), intraoperative (when surgeon starts tumor resection), immediately postoperative (30 min after the end of surgery)
Pain score (visual analogue scale, VAS)
Self-reported measures of symptoms that are recorded with a single handwritten mark placed at one point along the length of a 10-cm line that represents a continuum between the two ends of the scale-"no pain" on the left end (0 cm) of the scale and the "worst pain" on the right end of the scale (10 cm).
Time frame: postoperative 4 hour, 1 day, 2 day
Time to the first administration of rescue analgesics after the end of surgery
Time frame: postoperative (up to 2 weeks after surgery)
Total amounts of rescue analgesics
Time frame: postoperative (up to 2 weeks after surgery)
Total amounts of propofol and remifentanil administered during surgery
Time frame: intraoperative (from induction of anesthesia until end of anesthesia)
Time to emergence after the end of surgery
Time frame: postoperative (up to 1 day after surgery)
Time to extubation after the end of surgery
Time frame: postoperative (up to 1 day after surgery)
Incidence and severity of postoperative complications
nausea, vomiting, etc.
Time frame: postoperative (up to 2 weeks after surgery)
Hospital length of stay
Time frame: postoperative (up to 2 weeks after surgery)
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