Intravenous lipid emulsion is an established, effective treatment for local anesthetic systemic toxicity. It is also efficacious in animal models of severe cardiotoxicity caused by a number of other medications. Recent case reports of successful resuscitation suggest the efficacy of lipid emulsion infusion for treating non-local anesthetic overdoses across a wide spectrum of drugs. The present study will focus on the potential role of intravenous lipid emulsion as an adjuvant therapy in pesticides toxicity.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
62
Lipid emulsion is a mixture of soybean oil, egg phospholipids, glycerine, and is available in 10%, 20%, and 30% strengths. It has been used for decades as parenteral nutrition and for caloric supplementation and essential fatty acid deficiency. It has also been used as a carrier for lipid soluble medications
a drug used as an antidote for some types of pesticides
a drug used as an antidote for some types of pesticides
Poison Control Center of Ain-Shams University hospitals
Cairo, Abbasya, Egypt
RECRUITINGmortality rate reduction
the primary end point is to lower the mortality rate for patients poisoned with pesticides
Time frame: 1 year
organ damage reduction
another primary end point is to reduce organ damage and injury for survivors
Time frame: 1 year
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
standard of care for treatment of aluminuim phosphide is provided for patients poisoned with aluminuim phosphide