The objective of this project is to investigate the effects of blueberries on gut microbiota, inflammation and innate immunity in breastfed infants during early complementary feeding (\~5 to 12 months of age).
Some details are intentionally left to out to preserve the scientific integrity of the study, and they will be included in the record after the study is completed.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Enrollment
75
Administered one packet per day (10 grams/packet) and participants consume up to 10 grams per day.
Administered one packet per day (10 grams/packet) and participants consume up to 10 grams per day.
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States
Gut Microbiome Composition Analyzed using 16S rRNA Amplicon Sequencing
16S rRNA amplicon sequencing is used to profile taxonomic makeup of fecal specimens. Within the gut microbiome composition, microbial diversity will be summarized using common ecological measures (Good's coverage, Sobs, and Shannon alpha diversity).
Time frame: Over 7 months
Infant Growth (Length)
Measured in cm
Time frame: Over 7 months
Infant Growth (Weight)
Measured in kg
Time frame: Over 7 months
Dietary Intake
3 day dietary recall with results generated by NDSR software
Time frame: Over 7 months
Blueberry-Specific Food Signatures (Compounds) as Assessed by Metabolomics Analysis
Metabolomics analysis (nutri-metabolomics) is used to identify and validate food-derived biomarkers that may be classified as biomarkers of intake and/or biomarkers of effect, both of which can be linked to health indicators.
Time frame: Over 7 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.