Gut Microbiota in Major Depressive Disorders With and Without Rapid Eye Movement Behavior Disorder

Chinese University of Hong Kong55 enrolled

Overview

The purpose of this study is to identify the variations in gut microbiota compositions between two subtypes of major depressive disorder.

Objective: To identify the variations in gut microbiota compositions between two subtypes of major depressive disorder (MDD), namely those with and without REM sleep behavior disorder (RBD). To correlate the microbiota composition with depressive severity and prodromal markers of α-synucleinopathy. Design: Case-control study Setting: Established clinical cohorts consisting of patients with comorbid MDD+RBD and MDD only and a group of sexand age-matched healthy control Participants: Patients with comorbid MDD+RBD (n=55), patients with MDD only (n=55), and healthy control (n=55). Main outcome measures: The abundance and composition of gut microbiota, severity of depressive symptoms, and prodromal markers of α-synucleinopathy.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Gut Microbiota

Interventions

No interventionOTHER

No intervention

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age-and sex-matched with MDD+RBD subjects; 2. Free of psychiatric disorders based on M.I.N.I.; 3. Without a personal history or a family history of RBD or neurodegenerative diseases (i.e. dementia and PD) 4. Free of RBD symptoms or RWSA by vPSG Exclusion Criteria: 1. Presence of narcolepsy and other neurodegenerative diseases that may give rise to RBD and RWSA; 2. Severe psychiatric illness that could not permit a valid written informed consent or otherwise is not suitable for participating in a study; 3. Use of antibiotics within one month and the use of probiotics within three days prior to sample collection; 4. Pre-existing or post-operation of gastrointestinal diseases (e.g. inflammatory bowel disease, gastrointestinal cancer).

Locations (1)

Shatin Hospital

Shatin, Hong Kong

RECRUITING

Outcomes

Primary Outcomes

Composition of gut microbiota

Colonic fecal bacterial composition across two heterogeneous groups of MDD (with and without RBD) and a group of the sex- and age-matched healthy controls

Time frame: Day 0

Central Contacts

Mandy Yu, MPH

CONTACT

852-39197593 mandyyu@cuhk.edu.hk

Data from ClinicalTrials.gov

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