The purpose of this study is to identify early cardiovascular disease risk factors in those with "normal-weight obesity" (i.e., normal body, but high body fat percentage) that better track with their long-term cardiovascular disease risk.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
SCREENING
Masking
NONE
Enrollment
30
All participants will be given a high-fat test meal to examine their postprandial triglyceride response.
Oklahoma State University
Stillwater, Oklahoma, United States
4-hour triglycerides after fat tolerance test
Participants will undergo an abbreviated fat tolerance test, where fasting triglycerides are measured, a high-fat shake is consumed, and triglycerides measured once more 4 hours later. 4 hour triglycerides after the high-fat meal is our primary outcome.
Time frame: Within 2 weeks of study enrollment
Flow-mediated dilation
Flow-mediated dilation is a non-invasive technique to investigate vascular health. This technique will be performed when participants are fasting and \~4 hours after the shake is completed (just before final measurement of triglycerides)
Time frame: Within 2 weeks of study enrollment
Fasting serum cytokines
A number of cytokines including GM-CSF, IFN-gamma, IL-1beta, IL-2, IL-5, IL-6, IL-8, IL-12p70, IL-13, IL-17, TNF-alpha, IL-4, IL-10 will be measured as additional cardiovascular disease risk factors.
Time frame: Within 10 months of study enrollment
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