Hypotension Prediction Index in Living Donor Liver Transplantation

Seoul National University Hospital20 enrolled

Overview

The Hypotension Prediction Index via the Edwards Hemosphere advanced monitoring system is monitored in living donor liver transplantation recipients. The Hypotension Prediction Index is analyzed to verify the performance in predicting hypotensive events.

Hypotensive events during surgery and anesthesia occur frequently and are associated with complications such as myocardial infarction, acute kidney injury, and increase in mortality. Therefore predicting and preventing hypotension can lead to better outcomes. The Hypotension Prediction Index is monitored with the Edwards Hemosphere advanced monitoring system in living donor liver transplantation recipients via the radial artery. The monitor is blinded so that the anesthesiologist cannot see the index, and the anesthesiologist manages the blood pressure according to the institution's anesthetic protocol for liver transplantation. After the surgery is done, the Hypotension Prediction Index is analyzed to see how well the index predicted actual hypotension that occured during the liver transplantation surgery. Receiver operating characteristic curves are drawn to show the performance of the Hypotension Prediction Index in liver transplantation.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Living Donor Liver Transplantation Hypotension

Interventions

Hypotension Prediction IndexDEVICE

Hypotension Prediction Index monitored via radial arterial line

Eligibility

Sex: ALLMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients scheduled for living donor liver transplantation aged 20 years and older * Patients who understand the trial and have given informed consent Exclusion Criteria: * Patients with arrhythmia or pacemaker

Locations (1)

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Prediction of Hypotension 5 Minutes Before the Event

Receiver operating characteristic curve for the Hypotension Prediction Index, Comparison of the hypotensive event and the Hypotension Prediction Index 5 minutes before the event

Time frame: During the surgery

Secondary Outcomes

Prediction of Hypotension 10 Minutes Before the Event

Receiver operating characteristic curve for the Hypotension Prediction Index, Comparison of the hypotensive event and the Hypotension Prediction Index 10 minutes before the event

Time frame: During the surgery

Prediction of Hypotension 15 Minutes Before the Event

Receiver operating characteristic curve for the Hypotension Prediction Index, Comparison of the hypotensive event and the Hypotension Prediction Index 15 minutes before the event

Time frame: During the surgery

Data from ClinicalTrials.gov

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