The purpose of this experiment is to analyze wrinkle severity, the skin barrier and facial pigmentation level after topical almond oil application, compared to the use of topical retinol. Both the almond oil and the 0.5% topical retinol studied is investigational.
The natural cosmetic market is a multi-billion-dollar industry. Nutraceuticals and foodbased cosmetics are a growing trend within dermatology. Almonds are a rich dietary source of a range of fatty acids, phytochemical polyphenols, and antioxidants \[1\]. The previous study done by Dr. Raja Sivamani was a double blinded study that compared oral almond intake to a calorie matched non-nut-based intake over 12 weeks.The study determined that that there was a statistically significant improvement in wrinkle severity and pigment intensity in the women that received almond supplementation. This proposal aims to now understand how the topical application of almond oil may influence the appearance of wrinkles and facial tone in post-menopausal women. Almond oil is rich in fatty acids and alpha-tocopherol \[2\]. Tocopherol inhibits melanogenesis in melanocytes \[3\] and topical alpha tocopherol has been shown to improve skin antioxidants and hyperpigmentation \[4, 5\].
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
40
Almond Oil Pressed Cold
UC Davis Department of Dermatology, Clinical Trials Unit
Sacramento, California, United States
Appearance of wrinkle severity
Facial wrinkles will be assessed with the use of a validated high resolution facial modeling system. The high-resolution facial modeling system will be performed with the 3D Clarity Pro® Facial Modeling and Analysis System (Brigh-Tex BioPhotonics, San Jose, CA) and will specifically assess for wrinkle severity and wrinkle length as was performed in the previous pilot study.
Time frame: 12-weeks
Appearance of facial color tone and evenness
The facial color tone and evenness will be measured with a SkinColor Catch from Delfin Technologies. This device shows the RGB Colors, CIE L\*a\*b\* and L\*c\*h\* color space coordinates when the devivce is applied to the skin. Included is the link to the device (http://www.truesystem.co.kr/product/pdf/SkinColorCatch%20Brochure%202016.pdf).
Time frame: 12-weeks
Appearance of facial redness
We will quantify the presence of facial redness with a SkinColor Catch from Delfin Technologies. We will measure the RGB colors and average them from each participant for each of the visits. Skin pigment, including the presence of redness, will be measured using a SkinColorCatch from Delfin Technologies . This device shows the RGB Colors, CIE L\*a\*b\* and L\*c\*h\* color space coordinates when the devivce is applied to the skin. Included is the link to the device (http://www.truesystem.co.kr/product/pdf/SkinColorCatch%20Brochure%202016.pdf).
Time frame: 12-weeks
Subjective tolerability
To assess tolerability, we are going to use a Tolerability Assessment Questionnaire. The patient fills out the questionnaire on whether they currently have or had any itching, burning, stining, scaling, erythema, hypopigmentation or hyperpigmentation during application of the product. They measure any of the symptoms on a scale of 0-3, 0 being none, 3 being severe. They can also hand write any other effects that they noticed from the study.
Time frame: 12-weeks
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