Sleep is critical for health and quality of life; however, little is known about the prevalence or impact of non obstructive sleep apnea (non-OSA) sleep disorders in people with stroke. The proposed study aims to characterize the proportion of people with stroke that have non-OSA sleep disorders and their impact on recovery of activities of daily living, functional mobility, and participation along the continuum of recovery in people with stroke.
The overall goal in this project is to develop an in-depth understanding of the complex interplay between non-obstructive sleep apnea (non OSA) sleep disorders and recovery after stroke. Sleep is vital to overall health and quality of life. Abnormal or insufficient sleep is both a risk factor and consequence of stroke. Sleep also plays a critical role in motor learning, which is the foundation of rehabilitation strategies after stroke. Although there is a growing understanding of the interplay between sleep, stroke, and recovery in people with OSA these complex relationships in individuals post stroke with non OSA sleep disorders are not well understood. In order to develop targeted sleep interventions to support rehabilitation after stroke and promote optimal recovery, it is critical to gain a fuller understanding of the prevalence and impact of non OSA sleep disorders in people with stroke across the continuum of recovery. The specific objectives of this proposal will lay the necessary groundwork for this as investigators will characterize the proportion of people with stroke that have insomnia disorders, restless legs syndrome, and insufficient sleep; and evaluate the impact of these non OSA sleep disorders on recovery of activities of daily living, mobility/activity, and participation across the continuum of recovery after stroke. The study will take an innovative approach to measuring sleep, mobility/activity, and participation using a combination of techniques across the measurement spectrum that will include self-report questionnaires, clinic-based measures of capacity, and body worn sensors. The body worn sensors will include actigraphy to measure sleep parameters, activity monitors to measure mobility/activity levels, and Global Positioning System (GPS) units to measure participation. Additionally, investigators will apply innovative, big data tools from topological data analysis for a data driven approach to discover complex, structural, non-linear interdependent relationships among stroke, sleep, and recovery of mobility/activity, and participation. Upon completion of this study there will be an understanding of the prevalence and impact of non-OSA sleep disorders on recovery of function, mobility/activity, and participation across the continuum of recovery post stroke. This is an important, necessary step to develop appropriate sleep-based interventions to complement targeted rehabilitation strategies to enhance the health and quality of life in people with stroke.
Study Type
OBSERVATIONAL
Enrollment
200
Observe physical function and sleep disorder symptoms following stroke
Emory University
Atlanta, Georgia, United States
RECRUITINGKU Medical Center, The University of Kansas
Kansas City, Kansas, United States
RECRUITINGInstitute for Human Performance - Upstate Rehabilitation at IHP
Syracuse, New York, United States
ACTIVE_NOT_RECRUITINGUpstate University Hospital
Syracuse, New York, United States
RECRUITINGUpstate Community Hospital
Syracuse, New York, United States
SUSPENDEDGood Shepherd Rehabilitation Network
Allentown, Pennsylvania, United States
TERMINATEDFunctional independence with activities of daily living as measured by the Barthel index
The Barthel index is a measure of functional independence with activities of daily living; the score range is 0-100 with higher numbers indicating more independence
Time frame: 15 days post-stroke
Functional independence with activities of daily living as measured by the Barthel index
The Barthel index is a measure of functional independence with activities of daily living; the score range is 0-100 with higher numbers indicating more independence
Time frame: 60 days post-stroke
Functional independence with activities of daily living as measured by the Barthel index
The Barthel index is a measure of functional independence with activities of daily living; the score ranges 0-100 with higher numbers indicating more independence
Time frame: 90 days post-stroke
Level of disability according to the stroke impact scale
The stroke impact scale is a self-report measure of disability; scores range from 0-100 with higher numbers indicating better function
Time frame: 60 days post-stroke
Level of disability according to the stroke impact scale
The stroke impact scale is a self-report measure of disability; scores range from 0-100 with higher numbers indicating better function
Time frame: 90 days post-stroke
Daytime sleepiness according to the Epworth Sleepiness Scale
Epworth sleepiness scale is a self report measure describing likelihood of falling asleep during different circumstances; scores range from 0-24, with higher numbers indicating more sleepiness
Time frame: 15 days post-stroke
Daytime sleepiness according to the Epworth Sleepiness Scale
Epworth sleepiness scale is a self report measure describing likelihood of falling asleep during different circumstances; scores range from 0-24, with higher numbers indicating more sleepiness
Time frame: 60 days post-stroke
Daytime sleepiness according to the Epworth Sleepiness Scale
Epworth sleepiness scale is a self report measure describing likelihood of falling asleep during different circumstances; scores range from 0-24, with higher numbers indicating more sleepiness
Time frame: 90 days post-stroke
Insomnia severity as determined from the insomnia severity index
The insomnia severity index is a self report measure of insomnia severity; scores range from 0-28, with higher numbers indicating more severe insomnia
Time frame: 15 days post-stroke
Insomnia severity as determined from the insomnia severity index
The insomnia severity index is a self report measure of insomnia severity; scores range from 0-28, with higher numbers indicating more severe insomnia
Time frame: 60 days post-stroke
Insomnia severity as determined from the insomnia severity index
The insomnia severity index is a self report measure of insomnia severity; scores range from 0-28, with higher numbers indicating more severe insomnia
Time frame: 90 days post-stroke
Likely presence of restless legs syndrome as measured by the Cambridge Hopkins restless legs questionnaire
The Cambridge Hopkins restless legs questionnaire is a self report measure of presence and frequency of symptoms of restless legs syndrome; responses are scored according to an algorithm that provides yes/no for likely presence of restless legs syndrome.
Time frame: 15 days post-stroke
Likely presence of restless legs syndrome as measured by the Cambridge Hopkins restless legs questionnaire
The Cambridge Hopkins restless legs questionnaire is a self report measure of presence and frequency of symptoms of restless legs syndrome; responses are scored according to an algorithm that provides yes/no for likely presence of restless legs syndrome.
Time frame: 60 days post-stroke
Likely presence of restless legs syndrome as measured by the Cambridge Hopkins restless legs questionnaire
The Cambridge Hopkins restless legs questionnaire is a self report measure of presence and frequency of symptoms of restless legs syndrome; responses are scored according to an algorithm that provides yes/no for likely presence of restless legs syndrome.
Time frame: 90 days post-stroke
Cumulative morbidity of sleep disorders, as determined from the sleep disorders checklist, 25 item version
The sleep disorders checklist, 25 item version, is a self report questionnaire of frequency of occurrence of 25 sleep disorder symptoms; scores range from 0-100, with higher numbers indicating worse overall morbidity of sleep disorders.
Time frame: 15days post-stroke
Cumulative morbidity of sleep disorders, as determined from the sleep disorders checklist, 25 item version
The sleep disorders checklist, 25 item version, is a self report questionnaire of frequency of occurrence of 25 sleep disorder symptoms; scores range from 0-100, with higher numbers indicating worse overall morbidity of sleep disorders.
Time frame: 60days post-stroke
Cumulative morbidity of sleep disorders, as determined from the sleep disorders checklist, 25 item version
The sleep disorders checklist, 25 item version, is a self report questionnaire of frequency of occurrence of 25 sleep disorder symptoms; scores range from 0-100, with higher numbers indicating worse overall morbidity of sleep disorders.
Time frame: 90 days post-stroke
Degree of disability according to the modified Rankin scale
the modified Rankin scale is used to measure degree of disability in patients who have had a stroke; scores range from 0-5, with higher numbers indicating the most disability
Time frame: 15 days post-stroke
Degree of disability according to the modified Rankin scale
the modified Rankin scale is used to measure degree of disability in patients who have had a stroke; scores range from 0-5, with higher numbers indicating the most disability
Time frame: 60 days post-stroke
Degree of disability according to the modified Rankin scale
the modified Rankin scale is used to measure degree of disability in patients who have had a stroke; scores range from 0-5, with higher numbers indicating the most disability
Time frame: 90 days post-stroke
Balance ability according to the Berg balance scale
The Berg balance scale is an observational measure of balance ability according to performance on 14 tasks; scores range from 0-56, with higher scores indicating better balance
Time frame: 15 days post-stroke
Balance ability according to the Berg balance scale
The Berg balance scale is an observational measure of balance ability according to performance on 14 tasks; scores range from 0-56, with higher scores indicating better balance
Time frame: 60 days post-stroke
Balance ability according to the Berg balance scale
The Berg balance scale is an observational measure of balance ability according to performance on 14 tasks; scores range from 0-56, with higher scores indicating better balance
Time frame: 90 days post-stroke
Gait speed
Objective measure of gait speed from 10 meter walk test
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time frame: 15 days post-stroke
Gait speed
Objective measure of gait speed from 10 meter walk test
Time frame: 60 days post-stroke
Gait speed
Objective measure of gait speed from 10 meter walk test
Time frame: 90 days post-stroke
Activity level
Objective measure of activity according to leg-worn activity monitor to be analyzed according to manufacturer's algorithm.
Time frame: 15 days post-stroke
Activity level
Objective measure of activity according to leg-worn activity monitor to be analyzed according to manufacturer's algorithm.
Time frame: 60 days post-stroke
Activity level
Objective measure of activity according to leg-worn activity monitor to be analyzed according to manufacturer's algorithm.
Time frame: 90 days post-stroke
Types of community locations visited by study participants, as determined from global positioning sensor data
Objective measure of location of participant over a one week timeframe
Time frame: 60 days post-stroke
Types of community locations visited by study participants, as determined from global positioning sensor data
Objective measure of location of participant over a one week timeframe
Time frame: 90 days post-stroke
GG code for Mobility and Self Care Sections
Self care and functional mobility codes extracted from participants' medical records
Time frame: 15 days post-stroke
Daily activities as recorded by study participants (trip log)
tabulation of trip log - record of when they leave the house and where they are going.
Time frame: 60-days post-stroke
Daily activities as recorded by study participants (trip log)
tabulation of trip log - record of when they leave the house and where they are going.
Time frame: 90-days post-stroke
Cognitive ability according to the Montreal cognitive assessment
the Montreal cognitive assessment ratess participants' performance on several tasks as scored by a trained observer; scores range 0-30 with higher scores indicating better cognitive ability.
Time frame: 15 days post-stroke
Cognitive ability according to the Montreal cognitive assessment
the Montreal cognitive assessment ratess participants' performance on several tasks as scored by a trained observer; scores range 0-30 with higher scores indicating better cognitive ability.
Time frame: 60 days post-stroke
Cognitive ability according to the Montreal cognitive assessment
the Montreal cognitive assessment ratess participants' performance on several tasks as scored by a trained observer; scores range 0-30 with higher scores indicating better cognitive ability.
Time frame: 90 days post-stroke
Depression severity as measured by the patient health questionnaire (9-item version)
This is a self-report scale measuring frequency of depressive symptoms; scores range from 0-27 with higher scores indicating more severe depression
Time frame: 15 days post-stroke
Depression severity as measured by the patient health questionnaire (9-item version)
This is a self-report scale measuring frequency of depressive symptoms; scores range from 0-27 with higher scores indicating more severe depression
Time frame: 60 days post-stroke
Depression severity as measured by the patient health questionnaire (9-item version)
This is a self-report scale measuring frequency of depressive symptoms; scores range from 0-27 with higher scores indicating more severe depression
Time frame: 90 days post-stroke
Sleep diary
Tabulation of participant's sleep habits from a written diary, over a one week timeframe.
Time frame: 60 days post-stroke
Sleep diary
Tabulation of participant's sleep habits from a written diary, over a one week timeframe.
Time frame: 90 days post-stroke
Oxygen desaturation index
Oxygen desaturations per minute index, as determined from a pulse oximeter worn overnight
Time frame: 90 days post-stroke
Oxygen desaturation index
Oxygen desaturations per minute index, as determined from a pulse oximeter worn overnight
Time frame: 60 days post-stroke
Oxygen desaturation index
Oxygen desaturations per minute index, as determined from a pulse oximeter worn overnight
Time frame: 15 days post-stroke
Wrist actigraphy data
Data measured from a wrist-worn actigraph, to be analyzed according to manufacturer's algorithm
Time frame: 15 days post-stroke
Wrist actigraphy data
Data measured from a wrist-worn actigraph, to be analyzed according to manufacturer's algorithm
Time frame: 60 days post-stroke
Wrist actigraphy data
Data measured from a wrist-worn actigraph, to be analyzed according to manufacturer's algorithm
Time frame: 90 days post-stroke