This study plans to learn more about how consuming different foods during the time of early complementary feeding (\~5 to 12 months) affects growth and the development of bacteria living inside your baby's gut through school-age. The results from this study will potentially help to support future recommendations and dietary guidance for infant feeding practices. The three primary aims include: Aim 1. Identify the impact of dietary patterns with different protein-rich foods on infant growth. Aim 2. Identify the impact of dietary patterns with different protein-rich foods on infant gut microbiota development. Aim 3. Identify gut microbial taxa and genes that affect infant growth.
Some details are intentionally left to out to preserve the scientific integrity of the study, and they will be included in the record after the study is completed.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
267
Commercially available baby foods
Commercially available baby foods
Commercially available baby foods
Caregiver will provide participant with usual foods from the home
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States
Weight
Measured in kg
Time frame: Over 6 months
Length
Measured in cm
Time frame: Over 6 months
Body composition
Body fat mass, fat-free mass measured by stable isotopes
Time frame: Over 6 months
Gut Microbiome
Gut microbiota structure by 16S sequencing
Time frame: Over 6 months
Total calories in breast milk
Measured in kcal/100 mL
Time frame: Over 6 months
Total carbohydrates in breast milk
Measured in g/100 mL
Time frame: Over 6 months
Total protein in breast milk
Measured in g/100 mL
Time frame: Over 6 months
Total fat in breast milk
Measured in g/100 mL
Time frame: Over 6 months
Serum IGF-1 (Insulin-like growth factor1/ somatomedin C)
Measured in ng/mL
Time frame: Over 6 months
Serum IGFBP-3 (Insulin-like growth factor-binding protein 3)
Measured in ng/mL
Time frame: Over 6 months
Serum c-reactive protein (CRP-hs)
Measured in mg/L
Time frame: Over 6 months
Plasma alpha 1-acid glycoprotein (AGP)
Measured in mg/L
Time frame: Over 6 months
Dietary intake
3 day dietary recall with results generated by NDSR software
Time frame: Over 6 months
Food acceptance
Coded from behavioral observations and consumption measured in g
Time frame: Over 6 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.