The purpose of this study is to see if reducing the number of hours during which one eats each day will help reduce levels of LDL cholesterol and improve other markers of metabolic and cardiovascular health (i.e. blood sugar levels and blood pressure). The study also aims to assess changes in exercise capacity and trimethylamine N-oxide (TMAO) levels in response to Time Restricted Eating (TRE) and Intensive Cardiac Rehabilitation (ICR) versus ICR alone. TMAO is a metabolite, or a substance, produced during digestion and metabolism. Preliminary data illustrates a correlation between high levels of TMAO and higher risk of cardiovascular disease and mortality. We will also be looking at participants' long-term cardiovascular health status after they complete the ICR program.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
28
Participants in this arm will not have to adopt a 10-hour eating window while taking part in UCSD's 9-week ICR program.
Participants in this arm will adhere to a daily, consistent 10-hour eating window while undergoing UCSD's 9-week ICR program to see if there is an improvement on cardiometabolic parameters.
Altman Clinical and Translational Research Institute
La Jolla, California, United States
Change in Exercise Capacity (MetS)
Exercise Capacity
Time frame: Baseline and Week 1-9
Change in LDL cholesterol
LDL cholesterol (mg/dL)
Time frame: Baseline and Week 9
Change in non-HDL cholesterol
non-HDL cholesterol (mg/dL)
Time frame: Baseline and Week 9
Change in Triglycerides
Triglycerides (mg/dL)
Time frame: Baseline and Week 9
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.