Physical Training in Glioblastoma Patients During Cytotoxic Therapy

University Hospital Muenster54 enrolled

Overview

The aim of the present study is the prospective controlled use of physical activity in a collective of patients with glioblastoma after surgery and concomitant radiation/chemotherapy and during adjuvant cytotoxic therapy. The research question is whether physical exercise is feasible and whether patients benefit physically and mentally from the activities performed. For this purpose, specific training units under the supervision of a certified trainer and sports scientist as well as standardized sports medical test procedures are implemented. Beyond the instructed training, general physical activity phases are recorded electronically using a pedometer/activity tracker, which is worn at all times. It will be examined whether the individual training program 1. improves physical fitness 2. increases quality of life/life satisfaction throughout the intervention 3. can be detected in blood due to increased concentrations of brain-derived neurotrophic factor 1 (BDNF-1) (voluntary) The measurements should be taken before and 8, 16 and 24 weeks after the start of training.

The personal trainers of the university clinics in Bochum and Homburg/Saar receive specific training activities from Münster's trainer Ralf Brandt in order to ensure a standardized concept. This way, a comparison of the trainings' conduction and recording is possible both quantitatively and qualitatively.

Study Type

INTERVENTIONAL

Allocation

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Glioblastoma

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Newly diagnosed glioblastoma * Karnofsky Index ≥ 70 * Eastern Cooperative Oncology Group (ECOG) ≤ 2 * ≥ 18 years * Completed surgical therapy * Completed radiation and chemotherapy * Thrombocytes \> 50.000/µl * Hb \> 8 mg/dl * Ability to give consent * Mother tongue German/very good German skills Exclusion Criteria: * Diagnosed dementia (Mini-Mental-State-Test \< 24/30 points) * Pain (strong, permanent, restricting movement) * Impairment of consciousness * Fever * Acute infection * Pregnancy and lactation * Insufficiently adjusted epilepsy (despite anticonvulsive therapy \> 3 focal seizures per day or \> 1 generalized seizure in the previous 3 days)

Outcomes

Primary Outcomes

Increase in Physical Performance according to Physical Work Capacity (PWC) Test

Evidence of a significant increase (at least 15%) in physical work \[watt/kilogram bodyweight\] at PWC75% of maximum heart rate.

Time frame: Between week 0 and 16.

Secondary Outcomes

Physical Work Capacity (PWC)

PWC stratified according to: * age (\<40, 40-60, \>60 years) * Karnofsky performance status (KPS) (70-80 vs. 90-100 %) * Gender * PWC test 130, 150, (170)